Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).

Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study.

The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis patients.

45 sites with vertical intrabony alveolar defects will be selected. These defect sites will be allocated randomly into 3 groups as Group I, Group II and Group III.

• Group I will be treated with open flap debridement and filled with A-PRF
• Group II will be treated with open flap debridement and filled with Bioactive glass (Perioglas®)
• Group III will be treated with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.

Inclusion Criteria:

• Age: 25 to 55 years.
• Gender: Both males and females will be included in the study.
• Co-operative and motivated patients committed to oral hygiene.
• Patients exhibiting intrabony defects.

Exclusion Criteria:

• Patients with contraindication to periodontal surgery & local anesthesia.
• Any systemic disease affecting the bone density and outcome of periodontal therapy.
• Smokers, alcoholics, and patients with other adverse habits.
• Pregnant, nursing and menopausal women.
• Any known allergy/ hypersensitivity to any product used in this study.
• Patients on long-term systemic therapy (antibiotics, anti-inflammatory bisphosphonates, hormonal replacement therapy and any other), taking any drug known to have periodontal implications that may interfere with wound healing.
• Patients taking any anti-platelet and anticoagulant medication.
• Patients who have undergone periodontal treatment within a period of past 1 year.