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| Name | Class |
|---|---|
| Gazi University | OTHER |
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The aim of this split mouth, single-center, controlled study is to compare the healing of intrabony defects treated with a combination of Anorganic Bovine Bone Mineral (ABBM)/Platelet Rich Fibrin (PRF) or Anorganic Bovine Bone Mineral alone. The hypothesis being tested in the study was that PRF would augment the regenerative effects of ABBM in human intrabony defects.
Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intrabony defects. Platelet rich fibrin (PRF) is a new generation platelet concentrate with a simplified technique. Although there are some studies on the use of PRF in the treatment of intrabony defects, to date none of them evaluate its additive effects with ABBM. Therefore, a randomized, split mouth clinical trial was conducted to compare the healing of intrabony defects treated with a PRF/ABBM combination and to those obtained with ABBM alone. Using a split mouth design, 15 paired intrabony defects were randomly treated with either ABBM alone (control group) or with ABBM- PRF combination (test group). The following clinical parameters and radiographic measurements were recorded at baseline and six months postoperatively: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, the depth of the defect and defect angle
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRF and ABBM | Experimental | Intervention: Anorganic Bovine Bone Mineral and Platelet Rich fibrin is applied to the periodontal intrabony defects |
|
| Anorganic Bovine Bone Mineral | Active Comparator | Intervention: Anorganic Bovine Bone Mineral is applied to the periodontal intrabony defects |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anorganic Bovine Bone Mineral (ABBM) | Other | In the control group, periodontal intrabony defects were treated with ABBM alone. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level change: The distance from cemento-enamel junction to the depth of the sulcus recorded by a periodontal probe at baseline and 6 months postoperatively | baseline and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Vertical bone loss change: Distance between cemento-enamel junction and base of the defect measured in standardized radiographs at baseline and 6 months postoperatively | Baseline and 6 months | |
| Probing depth change: The distance from the gingival margin to the depth of the sulcus recorded by a periodontal probe at baseline and 6 months postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Levent Taner, PhD, DDS | Gazi University, Faculty of Dentistry, Department of Periodontology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yasemin Sezgin | Ankara | 06540 | Turkey (Türkiye) |
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| Anorganic Bovine Bone Mineral and Platelet Rich Fibrin (PRF) | Other | In the test group, periodontal intrabony defects were treated with ABBM and PRF combination. |
|
| baseline and 6 months |
| Radiographic defect angle change: Using the function 'angle' the defect angle can be measured by assessing the two lines that represent the root surface of the involved tooth and the bone defect surface at baseline and 6 months postoperatively | baseline and 6 months |
| ID | Term |
|---|---|
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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