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The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.
The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow.
MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bone marrow cellularity by mDixon-quant | Diagnostic Test | if trepanobiopsy was performed during the diagnosis, then comparison with MRI Bone marrow cellularity by mDixon-quant |
| Measure | Description | Time Frame |
|---|---|---|
| correlation between Bone marrow cellularity by mDixon-quant and trepanobiopsy. | Determination of bone marrow cellularity before starting therapy for the underlying disease. Cellularity according to trepanobiopsy data is the ratio of stromal and hematopoietic cells to fat cells in the bone marrow. Cellularity according to MRI - the ratio of water and fat in the bone marrow using the mDixom Quant. | Before the start of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| T1 maping | T1 mapping (ms) is a magnetic resonance imaging technique used to calculate the T1 time | Before the start of treatment |
| apparent diffusion coefficient | value of apparent diffusion coefficient in mm2/s |
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Inclusion Criteria:
presence of indications for performing trepanobiopsy:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nataliia Kriventsova | Contact | +7 (495)2876570 | 4508 | nataliya.krivencova@fccho-moscow.ru |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology | Recruiting | Moscow | Samory-Mashela,1 | 11198 | Russia |
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| ID | Term |
|---|---|
| D000741 | Anemia, Aplastic |
| ID | Term |
|---|---|
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D000080983 | Bone Marrow Failure Disorders |
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| Before the start of treatment |
| Percentage of the macromolecular proton fraction (MPF) | Percentage of the macromolecular proton fraction (MPF) | Before the start of treatment |
| Percentage of the bone marrow fat fraction | Percentage of the bone marrow fat fraction (FF) by spectroscopy | Before the start of treatment |
| D001855 | Bone Marrow Diseases |