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The primary purpose of this research is to determine if it is feasible to perform serial magnetic resonance imaging (MRI) to evaluate the amount of bone marrow cells (also called cellularity) and iron stores before and after bone marrow transplantation for severe sickle cell disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI arm | Experimental | Subjects with sickle cell disease undergoing bone marrow transplantation will undergo serial functional MRI (up to 4 scans). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| serial functional magnetic resonance imaging (MRI) | Diagnostic Test | All subjects with sickle cell disease undergoing bone marrow transplantation will undergo up to 4 functional MRI scans. |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of obtaining serial scans in patients with sickle cell undergoing marrow transplant | Feasibility will be measured by the number of subjects who undergo at least 2 of 4 scheduled functional MRI's | 110 days post transplant |
| Measure | Description | Time Frame |
|---|---|---|
| MRI and hemoglobin S. | Correlation between functional MRI result and hemoglobin S level. | 1 year post transplant |
| MRI and neutrophil engraftment | Correlation between functional MRI result and time to neutrophil engraftment |
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Inclusion Criteria:
Exclusion Criteria
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| Name | Affiliation | Role |
|---|---|---|
| Ghada Abusin, MBBS MS | University of Michigan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Ann Arbor | Michigan | 48109 | United States |
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| ID | Term |
|---|---|
| D000755 | Anemia, Sickle Cell |
| ID | Term |
|---|---|
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
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| 1 year post transplant |
| MRI and chimerism | Correlation between functional MRI result and time to donor/ recipient chimerism | 1 year post transplant |
| D006425 |
| Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |