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The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
A detailed medical history, questionnaires as well as blood, urine and placental samples will be used to analyse several factors leading to the high risk of preeclampsia in oocyte-donation pregnancies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy oocyte-donation pregnancy | healthy pregnancy | ||
| preeclamptic oocyte-donation pregnancy | preeclampsia | ||
| healthy IVF or ICSI pregnancy | healthy pregnancy | ||
| preeclamptic IVF or ICSI pregnancy | preeclampsia | ||
| healthy spontaneous conception pregnancy | healthy pregnancy | ||
| preeclamptic spontaneous conception pregnancy | preeclampsia |
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| Measure | Description | Time Frame |
|---|---|---|
| Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood. | T-Cell populations are altered in preeclampsia. HLA-mismatch of mother and donor oocyte lead to a "host-versus-graft" reaction. T-, B- and Natural killer cells are altered in placental tissue of oocyte-donation pregnancies. | 01.01.2020 - 01.12.2025 |
| Measure | Description | Time Frame |
|---|---|---|
| Preeclampsia in oocyte-donation pregnancies is caused by an activation of pro-inflammatory factors and endothelial dysfunction. | Altered Natural killer cells and B-cells in oocyte-donation pregnancies lead to endothelial dysfunction. Pro-inflammatory factors are higher in OD pregnancy and can be measured in placental tissue via single-cell sequencing. | 01.01.2020 - 01.12.2025 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Florian Herse, DSc | Contact | +49 30 450 540 434 | florian.herse@charite.de | |
| Judith Altmann, MD | Contact | judith.altmann@charite.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Experimental and Clinical Research Center (ECRC) | Recruiting | Berlin | 13125 | Germany |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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