Berlin-Brandenburg Pregnancy Cohort

Characterization of Immune Cell-trophoblast-interaction in Pregnancy Disorders

This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.

Inclusion Criteria:

• healthy pregnant women after giving informed consent
• pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes

Exclusion Criteria:

• infections
• alcohol and drug abuse
• manifest and chronic diseases