Comparison of Two Biphasic Insulin Regimens in Well-controlled Patients With the Use of Continuous Glucose Monitoring and New Glycemic Control Indices

A cross-over study of 36 well controlled people with type 2 Diabetes Mellitus who underwent 7-day Continuous Glucose Monitoring with Premixed Human Insulin 30/70 and subsequently with Biphasic Aspart 30.

Inclusion Criteria:

• regular attendees of Outpatient Clinic of the Diabetes Centre of the 1st Department of Internal Medicine of University Hospital in Thessaloniki Greece
• The patients were on Premixed Human Insulin 30/70 twice daily with or without metformin
• baseline HbA1c<7%

Exclusion Criteria:

• the presence of type 1 Diabetes Mellitus
• stage 4 Chronic Kidney Disease
• use of antidiabetic medications other than insulin and metformin
• major cardiovascular event during the last six months
• acute illness and hospitalization during the last two weeks
• pregnancy
• absence of good metabolic control assessed with self-monitoring of blood glucose during the week before entering the study (>20% of the measurements <80mg/dl or >130mg/dl)
• inability of the patients to understand the study procedures and sign the consent form

Upon request