Comparison of Premixed Insulins Aspart 30, Aspart 70 and Aspart on Postprandial Lipids

Comparison of the Impact of Biphasic Insulin Aspart 30 (BiAsp 30), Biphasic Insulin Aspart 70 (BiAsp 70) and Insulin Aspart on Postprandial Glucose and Lipid Metabolism During Two Consecutive Meals in Type 2 Diabetics.

The aim of the study is to investigate meal-related treatment with either premixed Insulin Aspart 30, Aspart 70 and Aspart with regard to postprandial glucose, triglyceride and free fatty acids excursions after a standard breakfast and lunch.

Whereas the effects of each of the established types of insulin (remixed Insulin Aspart 30, Aspart 70 and Aspart) have been shown before, their specific glucose and lipid lowering capacities have so far not been investigated in a simulated physiological situation.

Inclusion Criteria:

• Type-II Diabetes
• BMI > 27 kg/m2
• age 35 to 75 years
• HbA1c < 8.5%
• informed consent
• treatment with pre-mixed insulin
• stabile dose of insulin for at least 4 weeks

Exclusion Criteria:

• Type-I Diabetes mellitus
• HbA1c > 8.5 %
• Serum Creatinine > 1.7 mg/dl
• Alaninaminotranferase or Aspartataminotransferase > 3x Upper Limit of Normal
• treatment with sulfonylurea or gliptins
• treatment with glitazones
• manifest clinical infections
• treatment with glucocorticoids or antipsychotic drugs
• psychiatric diseases
• alcohol abuse
• myocardial infarction or stroke within the previous 3 months
• surgery within the previous 3 months