Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

Inclusion Criteria:

• For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
• For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.

Exclusion Criteria:

• Age superior to 65 years old,
• Active cancer