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The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism.
The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Unprovoked proximal deep vein thrombosis | |||
| Provoked distal deep vein thrombosis | |||
| age-matched control group with no history of vein thrombosis |
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| Measure | Description | Time Frame |
|---|---|---|
| DNMT3A mutations screening | Next generation sequencing | For sequencing analysis: 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| TET2, ASXL1, TP53, JAK2, SF3B1, SRSF2, GNB1, CBL, BCOR, SH2B3, PPM1D mutations screening | Next generation sequencing | For sequencing analysis: 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism (Distal/proximal; Provoked/unprovoked) and who has accepted that their DNA was kept and used in the context of research on venous thromboembolism
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nimes | Nîmes | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37300604 | Result | Guillotin F, Mercier E, Fortier M, Bouvier S, Jacquet Q, Dallo M, Chea M, Bourguignon C, Cochery-Nouvellon E, Perez-Martin A, Gris JC. Clonal haematopoiesis of indeterminate potential in patients with venous thromboembolism. J Thromb Thrombolysis. 2023 Aug;56(2):351-354. doi: 10.1007/s11239-023-02836-4. Epub 2023 Jun 10. |
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| ID | Term |
|---|---|
| D054556 | Venous Thromboembolism |
| ID | Term |
|---|---|
| D013923 | Thromboembolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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gDNA from leucocytes from a biobank (registration number DC-2008-290 and authorization number AC-2008-107)