The purpose of this study is to establish a clinical database for patients bearing at risk for ILD (Interstitial Lung Disease) and to set up a prospective ILD Screening program for these patients.

Inclusion Criteria:

• Age: ≥ 18 years
• patients with a known systemic disease bearing a risk for ILD
• signed informed consent (for prospective part)

Exclusion Criteria:

• Age < 18 years
• comorbidities severely limiting life-expectancy (e.g. severe cardiovascular conditions, malignant disease)

Patients (females and males; above 18 yrs) with a known systemic disease bearing a risk for ILD but without diagnosed ILD and patients (females and males; above 18 yrs) with diagnosed ILD.