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The cause of most interstitial lung diseases (ILDs) is still unknown. Further research, for example to determine predisposing genetic factors, is therefore needed. A database with relevant clinical data and DNA/serum samples of ILD patients could facilitate future research on the cause of ILDs.
Protocol title: 'Registration of clinical data and DNA of patients with Interstitial Lung Disease (ILD)' Rationale: The etiopathogenesis of most Interstitial Lung Diseases (ILDs) is still unknown. Further research, e.g. to determine predisposing genetic factors, is therefore needed. A database with relevant clinical data and DNA/serum samples of ILD patients could facilitate future research on the etiopathogenesis of ILDs.
Objective: Availability of relevant clinical data and DNA/serum samples of ILD patients in a database. Those data can be used for future research.
Study design: A prospective observational study
Study population: Patients diagnosed with ILD attending the pulmonology department in participating hospitals.
Intervention: a blood sample is taken from each patient. Furthermore, additional information is collected from the medical file.
Main study parameters/endpoints: DNA and serum sample, demographic variables, medical information, occupational history and hobbies.
Nature and extent of the burden and risks associated with participation, group relatedness: two tubes of blood will be drawn from the patients. The risks of drawing blood from a vein are minimal.
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| J.M.M. van den Bosch, M.D. | St. Antonius Hospital | Principal Investigator |
| J.C. Grutters, M.D. | St. Antonius Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Antonius Hospital | Nieuwegein | 3435CM | Netherlands | |||
| Diakonessenhuis |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38460070 | Derived | Drent M, Wijnen PA, Jessurun NT, Harmsze AM, Bekers O, Bast A. Drug-Gene Risk Stratification in Patients with Suspected Drug-Induced Interstitial Lung Disease. Drug Saf. 2024 Apr;47(4):355-363. doi: 10.1007/s40264-024-01400-0. Epub 2024 Mar 9. | |
| 34606062 | Derived | Jessurun NT, Drent M, Wijnen PA, Harmsze AM, van Puijenbroek EP, Bekers O, Bast A. Role of Drug-Gene Interactions and Pharmacogenetics in Simvastatin-Associated Pulmonary Toxicity. Drug Saf. 2021 Nov;44(11):1179-1191. doi: 10.1007/s40264-021-01105-8. Epub 2021 Oct 4. |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D012507 | Sarcoidosis |
| D011658 | Pulmonary Fibrosis |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
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| Utrecht |
| 3508 TG |
| Netherlands |
| Mesos Medisch Centrum | Utrecht | 3527 CE | Netherlands |
| UMC Utrecht | Utrecht | 3584 CX | Netherlands |
| D006425 | Hemic and Lymphatic Diseases |
| D006968 | Hypersensitivity, Delayed |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |