The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

Inclusion Criteria:

• 1) ≥ 20 years old Han Chinese;
• 2) living in Shenzhen for > 2 years;
• 3) free of liver diseases, renal diseases, and any cancers in the past 6 months; and
• 4) not in pregnancy for women.

Exclusion Criteria:

• 1) had severe organic diseases,
• 2) had acute infection symptoms, allergic diseases, and malignant tumors,
• 3) had a family history of genetic diseases,
• 4) took VD supplements in the past 6 months,
• 5) took medicines to control lipid levels within 12 hours, or
• 6) took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Adult volunteers visiting a health examination center in Shenzhen city of Guangdong province, China were recruited.

A total of 1,987 adults were included in the analysis, aged from 20 to 81 years old. Among them, there were 1,124 females aged 39 (31 - 49) years old and 863 males aged 36 (30 - 44) years old.