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The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
To characterize the acute effects of vaporized THC in women relative to men and to begin probing the mechanisms that may underlie gender differences.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Delta-9-Tetrahydrocannabinol (THC) | Active Comparator | 4 mg vaporized THC will be administered. |
|
| Placebo | Placebo Comparator | Inhaled placebo (no active cannabinoids) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Inhaled THC | Drug | 4 mg inhaled THC |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline: Rewarding Effects measured by Visual Analog Scale (VAS) | Subjective measure of THC induced "high" | Changes in "high" assessed over the following timepoints: baseline, +60, +80, +120, +180, +300 minutes after start of oral Dronabinol administration. |
| Change from Baseline: Verbal Learning: Measured by Rey Auditory Verbal Learning Test (RAVLT) | Measured as delay recall on the AVLT | Baseline and +80 minutes after start of oral Dronabinol administration. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carly Hewes, BS | Contact | 2039325711 | 7411 | carly.hewes@yale.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine | Recruiting | West Haven | Connecticut | 06516 | United States |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D013759 | Dronabinol |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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| Placebo | Drug | Inhaled placebo (no active cannabinoids) |
|