Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| THC | Active Comparator | Active THC (0.015mg/kg) administered intravenously over 10 minutes. |
|
| Placebo | Placebo Comparator | Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 10 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| THC | Drug | Active THC (0.015mg/kg) administered over 10 minutes |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Rewarding Effects measured by Visual Analog Scale (VAS) | subjective measure of THC induced "high" | changes in "high" assessed over the following timepoints: baseline, +10, +80, and +200 minutes after THC infusion begins |
| Verbal Learning: measured by Rey Auditory Verbal Learning Test (AVLT) | measured as delay recall on the AVLT | 25 minutes after THC infusion begins |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christina Luddy, BS | Contact | 203-932-5711 | 4549 | christina.luddy@yale.edu |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine | Recruiting | West Haven | Connecticut | 06516 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38832949 | Derived | Mohammad Aghaei A, Urban Spillane L, Pittman B, Flynn LT, De Aquino JP, Bassir Nia A, Ranganathan M. Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study. Psychopharmacology (Berl). 2024 Oct;241(10):2145-2155. doi: 10.1007/s00213-024-06625-6. Epub 2024 Jun 4. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D013759 | Dronabinol |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Placebo | Drug | Control: small amount of alcohol (quarter teaspoon), with no THC over 10 minutes |
|