Sulfur Amino Acids, Energy Metabolism and Obesity

Dietary Sulfur Amino Acid Restriction, Energy Metabolism and Obesity

The primary objective of the trial is to establish the effects of dietary sulfur amino acid (SAA) restriction on body weight, body composition and energy expenditure in humans.

Dietary SAA restriction is an established model for increasing lifespan and improving metabolic health in animal studies. Data from human studies are limited.

In this study the investigators will perform an 8-week dietary intervention with SAA restriction to characterise the effects on several parameters related to metabolic health including body weight, body composition, energy expenditure, lipid profile and gene expression profiles in adipose tissue. The aim is to translate findings from previous animal experiments to humans

Inclusion Criteria:

• Healthy participants with overweight and obesity (BMI 27-35 kg/m2)
• Waist circumference > 80 cm for women and > 94 cm for men

Exclusion Criteria:

• Smoking
• Presence of chronic disease
• Established co-morbidities
• Already on a vegan diet or have been the last month
• Pregnancy
• Breastfeeding the last 3 months
• Unstable body weight the last 3 months
• High intensity training > 3 times weekly