Extracellular Vesicles as Biomarkers for Chronic Renal Failure

Extracellular Vesicles as Biomarkers for Chronic Renal Failure

The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.

Inclusion Criteria:

• subject > 18 years old
• healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI
• CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²

Exclusion Criteria:

• patients under dialysis protocols
• renal transplant patients