Exercise and PRP vs Exercise Alone in Patients With Knee Osteoarthritis

The Combination of Exercise and PRP vs Exercise Alone in Patients With Knee Osteoarthritis: A Randomized Controlled Clinical Trial

This study is a prospective randomized controlled study of different treatments for knee osteoarthritis and aims to investigate the efficacy of exercise combined platelet rich plasma (PRP) injection versus only exercise or only PRP treatments.

Inclusion Criteria:

• Adults 40-70 years of age,
• Grade 2-3 according to Kellgren Lawrence osteoarthritis classification,
• No medication for knee osteoarthritis in the past three months,
• Subjects who understand and sign the consent form for this study.

Exclusion Criteria:

• Patients who have received an invasive procedure, intra-articular application and / or physiotherapy in the target knee within three months,
• Previous partial or total knee replacement of the target knee,
• Body mass index > 30 kg/m2,
• Having any cardiovascular diseases, neurological disorders, rheumatic diseases, malignancy or psychiatric diseases,
• Impaired cognition that impacts the ability to give informed consent,
• Participation in another clinical trial.