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The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CCTA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CCTA | Diagnostic Test | All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. |
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular events | Cardiac death and myocardial infarction | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Invasive coronary angiography | Invasive coronary angiography occurred at follow-up after CCTA, attributed to CCTA results or unplanned. | 10 years |
| Medication prescription | Change for medication prescription of antiplatelet agents, anti-ischemic drugs, lipid-lowering agents, angiotensin-converting enzyme inhibition and so on, attributed to CCTA results or unplanned, |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who were referred for CCTA for the assessment of SCP suspected of CAD.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jia Zhou | Contact | +8615522485560 | zhoujiawenzhang@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Chaoyang Hospital | Recruiting | Beijing | Beijing Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41721263 | Derived | Wang P, Chen T, He M, Xin T, Wang C, Zhao J, Tan Y, Zhou J. Comparison of coronary artery calcium score-based and all-coronary computed tomography angiography strategies in patients with stable chest pain and risk factor-weighted clinical likelihood of 5-15. BMC Med Imaging. 2026 Feb 20;26(1):161. doi: 10.1186/s12880-026-02232-3. | |
| 39076944 |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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|
| 10 years |
| Coronary revascularization | PTCA, PCI or CABG occurred at follow-up after CCTA, attributed to CCTA results or unplanned. | 10 years |
| Number of Participants with Death | 10 years |
| Number of Participants with Stroke | 3 years |
| Number of Participants with Cardiac death | 10 years |
| Number of Participants with Myocardial infarction | 10 years |
| Hebei Petrochina Central Hospital | Recruiting | Langfang | Hebei | China |
|
| Tianjin Chest Hospital | Recruiting | Tianjin | Tianjin Municipality | 300000 | China |
|
| Tianjin First Central Hospital | Recruiting | Tianjin | Tianjin Municipality | China |
|
| Tan Y, Liu C, Chen T, Li Y, Wang C, Zhao J, Zhou J. Coronary Artery Calcium Score-Weighted Clinical Likelihood Model Performance in Patients with Stable Chest Pain and Coronary Artery Calcium Scores of Zero. Rev Cardiovasc Med. 2024 Mar 4;25(3):85. doi: 10.31083/j.rcm2503085. eCollection 2024 Mar. |
| 37310243 | Derived | Zhou J, Li C, Zhang H, Liu C, Yang J, Zhao J, Hou Y, Tan Y, Wang H, Li Y, Xie C, Wang M, Wang C, Zhang E, Wang S, Zhao P, Shan D, Liang S, Gao Y, Huo Y, Cong H, Guo Z, Chen Y. Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry. Radiology. 2023 Jun;307(5):e222965. doi: 10.1148/radiol.222965. |
| 35345247 | Derived | Jiang H, Feng J, Feng C, Ren P, Ren K, Jin Y, Zhou J. Validation and Comparison of PROMISE and CONFIRM Model to Predict High-Risk Coronary Artery Disease in Symptomatic and Diabetes Mellitus Patients. Rev Cardiovasc Med. 2022 Mar 1;23(3):80. doi: 10.31083/j.rcm2303080. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |