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| Name | Class |
|---|---|
| Montreal Heart Institute | OTHER |
| University Hospital, Bordeaux | OTHER |
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This multinational, investigator-initiated registry aims to investigate clinical outcomes of patients undergoing transcatheter mitral valve replacement (TMVR). The registry primarily focuses on patients treated with TMVR in real-world clinical practice.
Patients evaluated for TMVR but not undergoing the procedure are no longer systematically included. Historical data may include such patients who subsequently underwent alternative treatments, including transcatheter edge-to-edge repair, mitral valve surgery, or medical/conservative therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transcatheter Mitral Valve Replacement (TMVR) | Patients with successful TMVR screening, who underwent Transcatheter Mitral Valve Replacement subsequently. All devices may be included. | ||
| Mitral transcatheter edge-to-edge repair (M-TEER) | Patients with TMVR screening failure, who subsequently underwent interventional mitral valve edge-to-edge repair. Update: These patients are currently no longer systematically included. | ||
| Mitral valve surgery (Surgery) | Patients with TMVR screening failure, who subsequently underwent mitral valve surgery (i.e., mitral valve repair or replacement). Update: These patients are currently no longer systematically included. | ||
| Medical/conservative therapy | Patients with TMVR screening failure, who subsequently underwent conservative or optimal medical therapy. Update: These patients are currently no longer systematically included. |
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| Measure | Description | Time Frame |
|---|---|---|
| Mitral insufficiency grade 2+ or more | Mitral insufficiency measured by transthoracic echocardiography. Assessment of MI severity according to current guidelines (ESC/EACTS and ACC/AHA) for valvular heart disease. | 12 months |
| Freedom from device-related complications | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Combined all-cause mortality or rehospitalization for congestive heart failure | 12 months | |
| All-cause mortality | 12 months | |
| Cardiovascular mortality |
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Inclusion Criteria:
Exclusion Criteria:
- age under 18 years
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This study aimes to include all patients with significant mitral insufficiency, who underwent screening for possible transcatheter mitral valve implantation (TMVI), irrespective of the subsequent therapy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sebastian Ludwig, MD | Contact | +494074100 | se.ludwig@uke.de | |
| Lena Strotmann, MD | Contact | +4074100 | L.Strotmann@uke.de |
| Name | Affiliation | Role |
|---|---|---|
| Lenard Conradi, MD | University of Cologne | Principal Investigator |
| Thomas Modine, MD | University Hospital, Bordeaux | Principal Investigator |
| Sebastian Ludwig, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tucson Medical Center | Recruiting | Tucson | Arizona | 85712 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40329826 | Derived | Ludwig S, Coisne A, Hamzi K, Ben Ali W, Scotti A, Koell B, Duncan A, Makkar R, Akodad M, Bleiziffer S, Nickenig G, Kaneko T, Ruge H, Adam M, Sondergaard L, Dahle G, Taramasso M, Walther T, Kempfert J, Obadia JF, Chehab O, Tang GHL, Goel S, Fam N, Denti P, Praz F, von Bardeleben RS, Hausleiter J, Latib A, Conradi L, Modine T, Pezel T, Granada JF; CHOICE-MI Investigators. Phenotypic clustering analysis of patients rejected for mitral valve interventions: implications for future transcatheter technologies. Eur Heart J Cardiovasc Imaging. 2025 Jul 31;26(8):1452-1463. doi: 10.1093/ehjci/jeaf141. | |
| 39243262 |
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| 12 months |
| Rehospitalization for congestive heart failure | Incidence of new-onset or worsening signs and symptoms of heart failure that required urgent therapy and resulted in hospitalization, e.g. as assessed by patient interviews. | 12 months |
| Combined cardiovascular mortality or rehospitalization for congestive heart failure | 12 months |
| Unplanned mitral valve intervention | Incidence of unplanned surgical or transcatheter re-intervention, heart transplantation or left ventricular assist device implantation, e.g. as assessed by patient interviews. | 12 months |
| Combined all-cause mortality, rehospitalization for congestive heart failure or unplanned mitral valve intervention | 12 months |
| Combined cardiovascular mortality, rehospitalization for congestive heart failure or unplanned mitral valve intervention | 12 months |
| New York Heart Association (NYHA) stage III or IV | Assessment of New York Heart Association (NYHA) classification stage (in- or outpatient) after 12 months follow-up, as assessed by patient interviews. | 12 months |
| University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf |
| Principal Investigator |
| Juan F Granada, MD | Cardiovascular Research Foundation, New York, USA | Principal Investigator |
| Cedars-Sinai Medical Center, Los Angeles | Recruiting | Los Angeles | California | 90048 | United States |
|
| Tampa General Hospital | Recruiting | Tampa | Florida | 33606 | United States |
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| Brigham and Women's Hospital | Recruiting | Boston | Massachusetts | 02115 | United States |
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| Minneapolis Heart Institute at Abbott Northwestern Hospital | Recruiting | Minneapolis | Minnesota | 55407 | United States |
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| Morristown Medical Center | Recruiting | Morristown | New Jersey | 07960 | United States |
|
| Montefiore Medical Center | Recruiting | New York | New York | 10461 | United States |
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| Oklahoma Heart Hospital | Recruiting | Oklahoma City | Oklahoma | 73120 | United States |
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| Houston Methodist Hospital | Recruiting | Houston | Texas | 77030 | United States |
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| St Vincent's Hospital | Recruiting | Sydney | Australia |
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| Medical University of Vienna | Recruiting | Vienna | Austria |
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| Québec Heart and Lung Institute (Laval University) | Recruiting | Québec | Quebec | G1V 4G5 | Canada |
|
| Toronto Heart Center | Recruiting | Toronto | Canada |
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| St. Paul's Hospital | Recruiting | Vancouver | Canada |
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| Rigshospitalet | Recruiting | Copenhagen | Denmark |
|
| CHU Bordeaux | Recruiting | Bourdeaux | France |
|
| Lille University Hospital | Recruiting | Lille | France |
|
| Civils Hospices of Lyon | Recruiting | Lyon | France |
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| Clinique Pasteur | Recruiting | Toulouse | France |
|
| HDZ Bad Oeynhausen | Recruiting | Bad Oeynhausen | Germany |
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| German Heart Center Berlin | Recruiting | Berlin | Germany |
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| Heart Center Bonn | Recruiting | Bonn | Germany |
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| University Hospital of Cologne | Recruiting | Cologne | Germany |
|
| Goethe-Universität - University Hospital Frankfurt | Recruiting | Frankfurt | Germany |
|
| University Heart and Vascular Center Hamburg | Recruiting | Hamburg | Germany |
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| University Heart Center Lübeck | Recruiting | Lübeck | Germany |
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| Heart Center of the University Medical Center Mainz | Recruiting | Mainz | Germany |
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| German Heart Centre Munich | Recruiting | Munich | Germany |
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| LMU Munich | Recruiting | Munich | Germany |
|
| University Medical Center Ulm | Recruiting | Ulm | Germany |
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| Interbalkan Medical Center | Recruiting | Thessaloniki | Greece |
|
| ASST Spedali Civili di Brescia | Recruiting | Brescia | Italy |
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| San Raffaele University Hospital | Recruiting | Milan | Italy |
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| IRCCS Humanitas Research Hospital | Recruiting | Milan | 20089 | Italy |
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| IRCCS Policlinico San Donato | Recruiting | Milan | Italy |
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| University Hospital of Pisa | Recruiting | Pisa | Italy |
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| Rikshospitalet, Oslo University Hospital (OUS) | Recruiting | Oslo | Norway |
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| Poznan University of Medical Sciences | Recruiting | Poznan | Poland |
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| Warsaw Medicover Hospital | Recruiting | Warsaw | Poland |
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| Inselspital Bern | Recruiting | Bern | Switzerland |
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| USZ Zurich | Recruiting | Zurich | Switzerland |
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| Royal Brompton Hospital | Recruiting | London | United Kingdom |
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| St Thomas' Hospital - London | Recruiting | London | United Kingdom |
|
| Derived |
| Coisne A, Ludwig S, Scotti A, Ben Ali W, Weimann J, Duncan A, Webb JG, Kalbacher D, Rudolph TK, Nickenig G, Hausleiter J, Ruge H, Adam M, Petronio AS, Dumonteil N, Sondergaard L, Adamo M, Regazzoli D, Garatti A, Schmidt T, Dahle G, Taramasso M, Walther T, Kempfert J, Obadia JF, Redwood S, Tang GHL, Goel S, Fam N, Metra M, Andreas M, Muller DW, Denti P, Praz F, von Bardeleben RS, Leroux L, Latib A, Granada JF, Conradi L, Modine T; CHOICE-MI Investigators. Outcomes Following Transcatheter Mitral Valve Replacement Using Dedicated Devices in Patients With Mitral Annular Calcification. JACC Cardiovasc Interv. 2024 Sep 23;17(18):2141-2153. doi: 10.1016/j.jcin.2024.07.038. Epub 2024 Sep 4. |
| 37194288 | Derived | Ludwig S, Conradi L, Cohen DJ, Coisne A, Scotti A, Abraham WT, Ben Ali W, Zhou Z, Li Y, Kar S, Duncan A, Lim DS, Adamo M, Redfors B, Muller DWM, Webb JG, Petronio AS, Ruge H, Nickenig G, Sondergaard L, Adam M, Regazzoli D, Garatti A, Schmidt T, Andreas M, Dahle G, Walther T, Kempfert J, Tang GHL, Redwood S, Taramasso M, Praz F, Fam N, Dumonteil N, Obadia JF, von Bardeleben RS, Rudolph TK, Reardon MJ, Metra M, Denti P, Mack MJ, Hausleiter J, Asch FM, Latib A, Lindenfeld J, Modine T, Stone GW, Granada JF; CHOICE-MI and the COAPT Trial Investigators. Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score-Matched Comparison. Circ Cardiovasc Interv. 2023 Jun;16(6):e013045. doi: 10.1161/CIRCINTERVENTIONS.123.013045. Epub 2023 May 16. |
| ID | Term |
|---|---|
| D008944 | Mitral Valve Insufficiency |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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