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This investigator-initiated, multicenter, international, retrospective registry aims to investigate outcomes of patients with atrial functional mitral regurgitation, as treated in clinical routine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mitral Valve Transcatheter Edge-to-Edge Repair (M-TEER) | Patients who underwent mitral valve transcatheter edge-to-edge repair. All devices may be included. | ||
| Guideline Directed Medical Therapy | Patients who underwent conservative management with guideline directed medical therapy. | ||
| Transcatheter Mitral Valve Replacement (TMVR) | Patients who underwent transcatheter mitral valve replacement. All devices may be included. |
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| Measure | Description | Time Frame |
|---|---|---|
| Composite of all-cause mortality and heart-failure related rehospitalitzation | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Residual Mitral Regurgitation ≤1+ | Rate of patients achieving residual mitral regurgitation ≤1+ measured by transthoracic echocardiography. Assessment of mitral regurgitation severity according to current guidelines (ESC/EACTS and ACC/AHA) for valvular heart disease. | 12 months |
| All-cause mortality |
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Inclusion Criteria:
Exclusion Criteria:
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This study aimes to include all patients with clinically significant mitral regurgitation of the atrial functional mitral regurgitation subtype, irrespective of the subsequent therapy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philipp von Stein, MD | Contact | 646-321-8145 | philipp.von-stein@uk-koeln.de | |
| Christos Iliadis, MD | Contact | +49-221-478-32401 | christos.iliadis@uk-koeln.de |
| Name | Affiliation | Role |
|---|---|---|
| Christos Iliadis, MD | Heart Center, Department III of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montefiore Medical Center | Recruiting | The Bronx | New York | United States |
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| 12 months |
| Cardiovascular mortality | 12 months |
| Heart failure related rehospitalization | Incidence of new-onset or worsening signs and symptoms of heart failure that required urgent therapy and resulted in hospitalization. | 12 months |
| Unplanned mitral valve intervention | Incidence of unplanned surgical or transcatheter re-intervention, heart transplantation or left ventricular assist device implantation. | 12 months |
| New York Heart Association (NYHA) class III or IV | Assessment of New York Heart Association (NYHA) classification stage (in- or outpatient), with the minimum of I (no symptoms) and the maximum of IV (dyspnea at rest), with higher values indicating worse functional capacity. | 12 months |
| 6 Minute Walking Distance | 12 months |
| St. Michael's Hospital | Recruiting | Toronto | Canada |
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| Bordeaux University Hospital | Recruiting | Bordeaux | France |
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| University Hospital Center of Nantes | Recruiting | Nantes | France |
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| LMU Klinikum | Recruiting | Munich | Bavaria | 81377 | Germany |
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| University Hospital Cologne | Recruiting | Cologne | North Rhine-Westphalia | 50937 | Germany |
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| HDZ Bad Oeynhausen | Recruiting | Bad Oeynhausen | Germany |
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| Heart Center Bonn | Recruiting | Bonn | Germany |
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| University Hospital of Düsseldorf | Recruiting | Düsseldorf | Germany |
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| University Heart and Vascular Center Hamburg | Recruiting | Hamburg | Germany |
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| University Hospital Schleswig-Holstein | Recruiting | Kiel | Germany |
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| Heart Center Leipzig at University of Leipzig | Recruiting | Leipzig | Germany |
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| Heart Center of the University Medical Center Mainz | Recruiting | Mainz | Germany |
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| University Heart Center Ulm | Recruiting | Ulm | Germany |
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| University of Brescia | Recruiting | Brescia | Italy |
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| San Raffaele University Hospital | Recruiting | Milan | Italy |
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| University of Pisa | Recruiting | Pisa | Italy |
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| Hospital Clinic of Barcelona | Recruiting | Barcelona | Spain |
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| Reina Sofia University Hospital | Recruiting | Córdoba | Spain |
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| University Hospital of León | Recruiting | León | Spain |
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| Asturias Central University Hospital | Recruiting | Oviedo | Spain |
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| University Hospital Alvaro Cunqueiro | Recruiting | Vigo | Spain |
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| ID | Term |
|---|---|
| D008944 | Mitral Valve Insufficiency |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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