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Background and purpose: Cigarette smoking would post threats to physical health. Even though studies suggested that long-term cigarette smoking would lead to cardiovascular diseases, pulmonary diseases, or even cancer development, the smoking population all around the world was still common. Before progressing into the disease stage, cigarette smokers might have presented decreasing exercise capacity, skeletal muscle function, and cardiac autonomic function as early signs of physiological function decline. The purposes of this study are (1) to investigate the difference in exercise capacity, skeletal muscle function, and cardiac autonomic function between smokers and never smokers, and (2) to test the hypothesis that cigarette smoking is an independent factor associated with exercise capacity.
Methods: This is a cross-sectional observational study. This study will invite 150 participants from community in Taipei City. The body composition will be analyzed by bioelectrical impedance analysis, and resting heart rate variability will be evaluated by the heart rate variability monitor. Besides, grip strength, exhale carbon monoxide concentration, pulmonary function test, respiratory muscle performance will be measured. Moreover, subject will have to fill up the Fagerström Test for Nicotine Dependence and Seven-Day Physical Activity Recall Questionnaire. Last will be the cardiopulmonary exercise testing. Statistical analyses will be performed by statistical software for social sciences (SPSS) statistical package v.21.0 for Windows. (IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.) Between-group comparisons of exercise capacity, skeletal muscle function and heart rate variability parameters will be performed using independent Student's t-test. Pearson's correlation coefficient will be used to test the correlations between outcome parameters. Stepwise regression analysis will be used to examine the independent association between smoking and exercise capacity after controlling for confounders. The α level will be set at 0.05. The results of this study would provide the early effects of cigarette smoking on physical function, and highlight the importance of early detection and intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| smokers | cigarette smokers male 20 ≤ age ≤ 45 years old female 20 ≤ age ≤ 55 years old |
| |
| never smokers | age and gender-matched non-smokers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Body Composition | Device | The subjects should lie in the supine position on a non-conducting surface for 5 min. 4 surface electrodes with cables will be attached to the right hand and ankle of subjects. |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal oxygen uptake | Maximal oxygen uptake, VO2max (ml/kg/min), as an indicator of exercise capacity. Cardiopulmonary exercise testing will be used to evaluate the maximal exercise capacity by a computer-controlled breath-by-breath metabolic measurement system (Carefusion Corporation, Yorba Linda, CA, USA) base on the treadmill. Bruce protocol, which is a graded treadmill evaluation protocol will be adopted. | After finishing all the other measurement. The measurement will be lasted 15 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle function | Skeletal muscle function will be assessed by measuring the grip strength of the dominant hand using a hand dynamometer (Jamar, Jackson, MI, USA). | After finishing heart rate variability and body composition measurement. The measurement will be lasted 5 minutes. |
| Cardiac autonomic function |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects will be invited from community in Taipei City
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University, College of Medicine, Department of Physical Therapy | Taipei | Zhongzheng | 100 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29346338 | Background | Jamal A, Phillips E, Gentzke AS, Homa DM, Babb SD, King BA, Neff LJ. Current Cigarette Smoking Among Adults - United States, 2016. MMWR Morb Mortal Wkly Rep. 2018 Jan 19;67(2):53-59. doi: 10.15585/mmwr.mm6702a1. | |
| 30175730 | Background | Chen YL, Wu SC, Chen YT, Hsiao PC, Yu YH, Ting TT, Chen CY, Tu YK, Huang JH, Yang HJ, Li CY, Strong C, Yen CF, Yen CF, Chen WJ. E-Cigarette Use in a Country With Prevalent Tobacco Smoking: A Population-Based Study in Taiwan. J Epidemiol. 2019 Apr 5;29(4):155-163. doi: 10.2188/jea.JE20170300. Epub 2018 Sep 1. |
| Label | URL |
|---|---|
| Health Promotion Administration, Ministry of Health and Welfare, Taiwan. Taiwan Tobacco Control Annual Report 2015. 2015. | View source |
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| Heart rate variability | Device | After supine quietly for 20 min, a lead I electrocardiogram will be taken for 5 min. |
|
| Grip Strength | Device | The participants will squeeze the hand dynamometer as hard as possible with the dominant hand. 3 successive measurements will be taken. |
|
| Exhale Carbon Monoxide Concentration | Device | Subjects in sitting position, performing 1 inspiration, then exhale to carbon monoxide meter. |
|
| Pulmonary Function Test | Device | Subjects should be in a sitting position with a nose clip, then perform pulmonary function test. Participants should perform at least 3 acceptable attempts, but no more than 8 attempts in total. |
|
| Respiratory Muscle Function | Device | Subject will perform both maximal inspiratory pressure and maximal expiratory pressure for 3 times in sitting position with the nose clip. |
|
| Fagerström Test for Nicotine Dependence | Behavioral | Fagerström Test for Nicotine Dependence Traditional Chinese version will be adopted. It is a 6-item questionnaire that could help quantify the smoking frequency, amounts, and level of dependence. |
|
| Seven-Day Physical Activity Recall Questionnaire | Behavioral | Physical activity will be measured by the Chinese Version of the Seven-Day Physical Activity Recall Questionnaire. Participants will need to recall the time (hours) they spent in various leisure activities in the past 7 days. |
|
| Cardiopulmonary exercise testing | Device | Bruce protocol as the treadmill evaluation protocol will be adopted for cardiopulmonary exercise testing. |
|
Heart rate variability will be measured by HRV monitor (8Z11, Wegene Technology Inc., Taiwan) in this study. |
| After body composition measurement. The measurement will be lasted 20 minutes. |
| Skeletal muscle mass | Skeletal muscle mass (kilogram, kg) will be measured by a bioelectrical impedance analyzer (BIA). (Maltron BioScan 920, Maltron International Ltd., Esgender, UK). The subjects should lie in the supine position on a non-conducting surface for 5 min. Skeletal muscle mass will be calculated by the equation of Janssen and colleagues. | After collecting basic data of subjects. The measurement will be lasted 5-10 minutes. |
| Exhale carbon monoxide concentration | Exhale carbon monoxide will be measured by the carbon monoxide meter (CO Check+, MD Diagnostics LTD) for current smoking status evaluation. | After finishing heart rate variability and body composition measurement. The measurement will be lasted 1-3 minutes. |
| Forced expiratory volume in one second | Pulmonary function will be measured by a portable MicroLab® Spirometer (CareFusion, Basingstoke, UK). The outcome measure will include: forced expiratory volume in one second (FEV1, unit: liter). | The pulmonary function measurement will be lasted 15 minutes. |
| Forced vital capacity | Pulmonary function will be measured by a portable MicroLab® Spirometer (CareFusion, Basingstoke, UK). The outcome measure will include: forced vital capacity (FVC, unit: liter) | The pulmonary function measurement will be lasted 15 minutes. |
| FEV1/FVC ratio | Pulmonary function will be measured by a portable MicroLab® Spirometer (CareFusion, Basingstoke, UK). The outcome measure will include: FEV1/FVC ratio, which is useful for detecting possible dysfunction of the respiratory system in clinical practice. | The pulmonary function measurement will be lasted 15 minutes. |
| Respiratory muscle function | Maximal inspiratory pressure (PImax, unit: cmH2O) and maximal expiratory pressure (PEmax, unit: cmH2O) will be measured by a respiratory pressure meter, which could represent the respiratory muscle strength. | After pulmonary function test measurement. The measurement will be lasted 10 minutes. |
| Level of nicotine dependence | Fagerström Test for Nicotine Dependence (FTND) Traditional Chinese version will be adopted for quantifying the level of nicotine dependence. FTND is a 6-item questionnaire. The minimum value is 0 points and maximum values is 6 points. The higher score represents the greater nicotine dependence. | After respiratory muscle function measurement. The measurement will be lasted 3-5 minutes. |
| Seven-day physical activity recall questionnaire | Physical activity will be measured by the Chinese Version of the Seven-Day Physical Activity Recall Questionnaire. Participants will need to recall the time (hours) they spent in various leisure activities in the past 7 days. The energy expenditure (kcal/day) = metabolic equivalents (METs)*time (hour)*body weight (kg)/7 days. | After respiratory muscle function measurement. The measurement will be lasted 3-5 minutes. |
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| ID | Term |
|---|---|
| D000073865 | Cigarette Smoking |
| ID | Term |
|---|---|
| D000073869 | Tobacco Smoking |
| D012907 | Smoking |
| D001519 | Behavior |
| D064424 | Tobacco Use |
Not provided
Not provided
| ID | Term |
|---|---|
| D018737 | Hand Strength |
| D012129 | Respiratory Function Tests |
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D053580 | Muscle Strength |
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D003948 | Diagnostic Techniques, Respiratory System |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
Not provided
Not provided