The deficiency of vitamin D is common in patients with gastrointestinal system disorders.

Vitamin D has been associated with chronic non-specific musculoskeletal pain and migraines due to anti-inflammatory effects.

This prospective observational study will undergo elective laparoscopic cholecystectomy surgery between 18 and 65 years, is planned to participate in ASA (American Society of Anesthesiologists) 1-3, 90 volunteer patients.

In preoperative evaluation, the remaining 3 ml of blood was centrifuged from the routine received blood to determine the level of vitamin D will be kept.

Postoperative will be applied to patient controlled analgesia to all patients for 24 hours.

To determine the level of postoperative pain, the visual analog scale (VAS) will be used in the clock unit and at the service 6, 12 and 24 hours.

In this study, the investigators aimed to test the hypothesis of relation to pain and opioid consumption in acute postoperative (24 hours) of perioperative low-vitamin D.

Inclusion Criteria:

• Volunteer,
• Between the Ages Of 18-65,
• Least Primary School Graduate,
• Not Using Drugs That May Affect Cognitive Functions,
• Non-Alcohol Substance Use,
• Patients Without Psychiatric and Neurological Disease.

Exclusion Criteria:

• Those with known psychiatric disease and drugs,
• Those with an important cardiovascular or central nervous system disease,
• Patients with pain syndromes or routinely using opioid.

Very urgent patients

Volunteer patients undergoing elective laparoscopic cholecystectomy surgery by the Department of General Surgery