Anti-ageing Efficacy of a Cosmetic Formulation Containing NMN (2%) Versus Placebo

Efficacy Evaluation of the Anti-ageing Effect of a Cosmetic Active Versus Placebo

The study aims at evaluating skin wrinkling, puffiness and fatigue and dark circle appearance on asian and african-american healthy volunteer cohorts receiving a cosmetic formulation containing NMN (2%). The product will be evaluated after 28 and 56 days of twice-daily application in comparison with a reference cosmetic formulation using clinical scoring under dermatological control. Cosmetic acceptability and future use will also be subjectively evaluated by analysis of the subjects answers to an evaluation questionnaire.

Inclusion Criteria:

• Healthy subject
• Subject having given her free informed, written consent
• Subject willing to adhere to the protocol and study procedures
• Subject with normal frontal temperature lower than 37.5°c/100.4°F
• Subject has read and understood the information given by the investigator related to protection against Novel Coronavirus 19 and necessity to contact the investigator in case of any suspicion of COVID related manifestation (increase of frontal temperature, cough, sore muscles, weakness…) during the study

Exclusion Criteria:

• Pregnant or nursing woman or woman planning to get pregnant during the study
• Start, stop or change in hormonal treatment (including contraceptive pill) <1.5 months
• Cutaneous pathology on the study zone (face)
• Use of topical or systemic treatment during the previous weeks liable to interfere with the assessment of the cutaneous efficacy of the study product
• Subject having undergone a surgery under general anesthesia within the previous month
• Know allergy to certain cosmetic or dermato-pharmaceutic products
• Subject having done injections on face and/or a lifting
• Excessive exposure to sunlight or UV-rays within the month preceding the study