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| Name | Class |
|---|---|
| Eurofins | INDUSTRY |
| LGD | INDUSTRY |
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The study aims at evaluating skin wrinkling, puffiness and fatigue and dark circle appearance on asian and african-american healthy volunteer cohorts receiving a cosmetic formulation containing NMN (2%). The product will be evaluated after 28 and 56 days of twice-daily application in comparison with a reference cosmetic formulation using clinical scoring under dermatological control. Cosmetic acceptability and future use will also be subjectively evaluated by analysis of the subjects answers to an evaluation questionnaire.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asian skin | Twice-daily application for 55 Days |
| |
| African-American skin | Twice-daily application for 55 Days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Test product creme | Other | twice daily application of creme containing 2% NMN |
|
| Measure | Description | Time Frame |
|---|---|---|
| Wrinkles | clinical grading under dermatological control using 1) a 7 points Visual scale of Bazin from absence (0) to pronounced wrinkles (6) for the Asian panel and 2) a 5 points Visual scale of Bazin from absence (0) to pronounced wrinkles (4) for the Afro-American panel | Change from baseline (day 0) at days 28 and 56 of application |
| Eye bags | clinical grading under dermatological control using 1) a 7 points Visual scale of Bazin from absence (0) to pronounced bags (6) for the Asian panel and 2) a 6 points Visual scale of Bazin from absence (0) to pronounced bags (5) for the Afro-American panel | Change from baseline (day 0) at days 28 and 56 of application |
| Dark circles | clinical grading under dermatological control using 1) a 6 points Visual scale of Dermscan from absence (0) to important dark circles (6) for the Asian panel and 2) a 5 points Visual scale of Dermscan from absence (0) to important dark circles (4) for the Afro-American panel | Change from baseline (day 0) at days 28 and 56 of application |
| Relaxed features | clinical grading under dermatological control using a 11 points Non structured scale from relaxed features (0) to looking tired (10) for both panels | Change from baseline (day 0) at days 28 and 56 of application |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective evaluation of the product agreeableness and its effects on skin texture, moisture, puffiness, brightness, youth, swelling, wrinkling, radiance and tone. | Self-assessment questionnaire on a 5 points scale from "I disagree" (-2) to "I agree" (+2). | At day 28 of application |
| Subjective evaluation of the product agreeableness and its effects on skin texture, moisture, puffiness, brightness, youth, swelling, wrinkling, radiance and tone. |
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Inclusion Criteria:
Exclusion Criteria:
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Type: Chinese and Afro-American subjects
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| Name | Affiliation | Role |
|---|---|---|
| Corinne BENIER | Dermscan | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eurofins CRL Cosmetics Inc | Piscataway | New Jersey | 08854 | United States | ||
| Eurofins China |
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| ID | Term |
|---|---|
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Reference creme | Other | twice daily application of reference creme |
|
Self-assessment questionnaire on a 5 points scale from "I disagree" (-2) to "I agree" (+2). |
| At day 56 of application |
| Guangzhou |
| 510289 |
| China |