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Magnetic resonance imaging (MRI) is a diagnostic tool in medicine that generates high quality images of the human body without the use of x-rays. Volunteers will be asked to participate in a study to evaluate improved MRI hardware that can be used to enhance the ability of MRI as a diagnostic tool. Specifically, this hardware is designed to acquire high quality images of the brain. This MRI hardware will eventually be integrated into a positron emission tomography (PET) system, which will be able to detect trace amounts of brain disease and/or brain function simultaneously with MRI. The combined system is known as a PET/MRI. For the purposes of this test, the investigators are just evaluating the MRI hardware, which will be installed in a plastic mockup of the PET system.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Volunteers | Other | BrainPET insert |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IH 1Tx32Rx Head Array | Device | BrainPET insert |
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| Measure | Description | Time Frame |
|---|---|---|
| Quantitative equivalence or improvement of MRI image quality relative to the current mMR Array | (i) Quantitative Analysis: MRI data will be acquired and analyzed to assess image homogeneity, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) for identical MRI pulse sequences acquired with each RF coil. In addition, we will assess quality parameters such as the g-factor and noise correlation coefficients of each coil for different acceleration factors in both phantoms and volunteers. Simple statistical tests like the paired Student's t-test will be applied to any metrics | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Qualitative equivalence or improvement of MRI image quality relative to the current mMR | (i) Qualitative Analysis: Trained readers will search for visually discernible artifacts, compare image quality (subjective measures of contrast, noise and resolution) and check whether the Tx/Rx Array will provide similar clinical diagnostic accuracy (sensitivity and specificity) to the mMR Array. | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Joseph's Health Care, London | London | Ontario | N6A 4V2 | Canada |
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