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A prospective, randomized comparative study on adult patients with synechial angle closure glaucoma.
Patients were randomized into two groups: group A : patients will undergo two site phacoemulfication combined with trabeculectomy Group B with Phacoemulsification combined with ab-externo trabeculotomy. Preoperative assessments including full ophthalmic examination, anterior segment Optical Coherence Tomography (OCT) of the angle , endothelial cell count , visual fiend Perimetry and Biometry. Patients were followed up: first day, first week and every two months for 6 month. We will compare adverse effects and outcomes in both groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phacoemulsification combined with trabeculectomy | Active Comparator | Patients will undergo Two site phacoemulsification combined with trabeculectomy with Mitomycin C |
|
| Phacoemulsificaiton combined with ab-externo trabeculotomy | Active Comparator | Patients will undergo two phacoemulsification combined with deep sclerectomy and ab-externo trabeculotomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phacoemulsification combined with trabeculectomy | Procedure | Patients with chronic angle closure glaucoma assigned to this group will have fornex based trabeculectomy at superior limbus and then phacoemulsification via temporal incision |
| Measure | Description | Time Frame |
|---|---|---|
| Absolute Success | Reduction of IOP more than 30% on no glaucoma drops | 1,3,6 months |
| Visual outcome | Uncorrected visual acuity by Snellen's chart | 1,3,6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events | all intraoperative and postoperative adverse events witt be recorded | 1 week, 1 month, 3 months, 6 months |
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Inclusion Criteria:
Patients with chronic angle closure glaucoma, with or without peripheral anterior synechiae, age more than 18
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut University Hospital | Asyut | 7125 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11713061 | Background | Lichter PR, Musch DC, Gillespie BW, Guire KE, Janz NK, Wren PA, Mills RP; CIGTS Study Group. Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology. 2001 Nov;108(11):1943-53. doi: 10.1016/s0161-6420(01)00873-9. | |
| 12466166 | Background |
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All of the individual participant data in the study , after completion after de-identification
after publication and for five years
Anyone who wants to access data
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| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D005901 | Glaucoma |
| D015812 | Glaucoma, Angle-Closure |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
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| ID | Term |
|---|---|
| D014130 | Trabeculectomy |
| ID | Term |
|---|---|
| D018463 | Filtering Surgery |
| D013508 | Ophthalmologic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| Phacoemulsificaiton combined with ab-externo trabeculotomy | Procedure | Patients with chronic angle closure glaucoma assigned to this group will have Deep Sclerectomy with ab externo trabeculotomy at superior limbus and then phacoemulsification via temporal incision |
|
| Rebolleda G, Munoz-Negrete FJ. Phacoemulsification in eyes with functioning filtering blebs: a prospective study. Ophthalmology. 2002 Dec;109(12):2248-55. doi: 10.1016/s0161-6420(02)01246-0. |
| 31702714 | Background | Hansapinyo L, Choy BNK, Lai JSM, Tham CC. Phacoemulsification Versus Phacotrabeculectomy in Primary Angle-closure Glaucoma With Cataract: Long-Term Clinical Outcomes. J Glaucoma. 2020 Jan;29(1):15-23. doi: 10.1097/IJG.0000000000001397. |
| 28264221 | Background | Toteberg-Harms M, Wachtl J, Schweier C, Funk J, Kniestedt C. Long-term efficacy of combined phacoemulsification plus trabeculectomy versus phacoemulsification plus excimer laser trabeculotomy. Klin Monbl Augenheilkd. 2017 Apr;234(4):457-463. doi: 10.1055/s-0043-100291. Epub 2017 Mar 6. |