Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis

Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis According to Diagnostic Certainty

In this retrospective cohort study of patients with early Lyme neuroborreliosis (LNB), clinical and microbiologic characteristics and long-term outcome of definite vs. possible LNB were evaluated at a single university medical center in Slovenia. Severity of acute disease and long-term outcome during a 12-month follow-up were assessed using a composite clinical score based on objective clinical findings and subjective complaints.

Inclusion Criteria:

• early Lyme neuroborreliosis

Exclusion Criteria:

• Not fulfilling study criteria for definite or possible Lyme neuroborreliosis
• Alternative diagnosis during follow-up
• Concomitant tick-borne encephalitis
• Clinical symptoms/signs present for >6 months
• Data not available