Aseptic Meningoencephalitis in Slovenia

Prospective Study of the Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia

The main objective of this study is:

• to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia
• to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis
• to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with tick-borne encephalitis and Lyme neuroborreliosis

Inclusion Criteria:

• clinical picture compatible with aseptic meningitis/meningoencephalitis
• age 18 years or older
• clear cerebrospinal fluid on macroscopic examination
• cerebrospinal pleocytosis (> 5 x 106 white blood cells per liter)

Exclusion Criteria:

• younger than 18 years
• pregnant women