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Investigation of the biomechanical properties of the periodontal tissues in patients with periodontal disease. Non-surgical periodontal therapy will be assessed between baseline and 30 post-op by general clinical measurements (KT, PPD, CAL, BOP) as well as by biomechanical analysis and compared.
The study is designed as a prospective single center comparative clinical trial to investigate the biomechanical properties of the periodontal tissues in 30 patients with periodontal disease.
Success of non-surgical periodontal therapy between baseline and 30 post-op will be assessed by general clinical measurements (KT, PD, CAL, BOP) as well as by biomechanical analysis. Besides assessment for regular treatment effectiveness, safety parameter such as wound healing and adverse events will be assessed.
Additionally 10 periodontally healthy persons without local inflammation and bone loss shall be monitored and used a control group for reference to the test teeth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| periodontal treatment | Experimental | non-surgical root debridement |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| periodontal treatment | Other | non-surgical root debridement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Probing depth (PPD) at test tooth | mean PPD (mm) | 3 months |
| Bleeding on Probing (BoP) | mean BoP (%) | 3 months |
| Clinical attachment level (CAL) | mean attachment level (mm) | 3 months |
| Biomechanical analysis | Tooth displacement (mm) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Biotype/keratinized tissue width (KT) | mean - keratinized tissue width (KT) | 3 months |
| 1.General Oral Health Assessments Indices (GOHAI) | Limit the kinds of food - Questionaire by visual analogue scale (VAS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Søren Jepsen, PhD | University of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poliklinik für Parodontologie, Zahnerhaltung und Präventive Zahnheilkunde | Bonn | North Rhine-Westphalia | 53111 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21679952 | Result | Drolshagen M, Keilig L, Hasan I, Reimann S, Deschner J, Brinkmann KT, Krause R, Favino M, Bourauel C. Development of a novel intraoral measurement device to determine the biomechanical characteristics of the human periodontal ligament. J Biomech. 2011 Jul 28;44(11):2136-43. doi: 10.1016/j.jbiomech.2011.05.025. Epub 2011 Jun 15. | |
| 26395824 |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D010512 | Periodontal Index |
| ID | Term |
|---|---|
| D003753 | Dental Health Surveys |
| D006306 | Health Surveys |
| D011795 | Surveys and Questionnaires |
| D003625 | Data Collection |
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prospective single center comparative clinical trial to investigate the biomechanical properties of periodontal tissues
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| 3 months |
| 2.General Oral Health Assessments Indices (GOHAI) | Trouble biting or chewing - Questionaire by visual analogue scale (VAS) | 3 months |
| 3.General Oral Health Assessments Indices (GOHAI) | Problems to swallow comfortably - Questionaire by visual analogue scale (VAS) | 3 months |
| 4.General Oral Health Assessments Indices (GOHAI) | Problems to speak clearly - Questionaire by visual analogue scale (VAS) | 3 months |
| 5.General Oral Health Assessments Indices (GOHAI) | Discomfort when eating any kind of food - Questionaire by visual analogue scale (VAS) | 3 months |
| 6.General Oral Health Assessments Indices (GOHAI) | Limit contact with people - Questionaire by visual analogue scale (VAS) | 3 months |
| 7.General Oral Health Assessments Indices (GOHAI) | Pleased with look of teeth- Questionaire by visual analogue scale (VAS) | 3 months |
| 8.General Oral Health Assessments Indices (GOHAI) | Used medication to relieve pain- Questionaire by visual analogue scale (VAS) | 3 months |
| 9.General Oral Health Assessments Indices (GOHAI) | Worried about teeth, gums or dentures - Questionaire by visual analogue scale (VAS) | 3 months |
| 10.General Oral Health Assessments Indices (GOHAI) | Self-conscious of teeth, gums or dentures - Questionaire by visual analogue scale (VAS) | 3 months |
| 11.General Oral Health Assessments Indices (GOHAI) | Uncomfortable eating in front of others - Questionaire by visual analogue scale (VAS) | 3 months |
| 12.General Oral Health Assessments Indices (GOHAI) | Sensitive to hot, cold or sweet foods - Questionaire by visual analogue scale (VAS) | 3 months |
| Keilig L, Drolshagen M, Tran KL, Hasan I, Reimann S, Deschner J, Brinkmann KT, Krause R, Favino M, Bourauel C. In vivo measurements and numerical analysis of the biomechanical characteristics of the human periodontal ligament. Ann Anat. 2016 Jul;206:80-8. doi: 10.1016/j.aanat.2015.08.004. Epub 2015 Sep 12. |
| 32299416 | Result | Keilig L, Goedecke J, Bourauel C, Daratsianos N, Dirk C, Jager A, Konermann A. Increased tooth mobility after fixed orthodontic appliance treatment can be selectively utilized for case refinement via positioner therapy - a pilot study. BMC Oral Health. 2020 Apr 16;20(1):114. doi: 10.1186/s12903-020-01097-4. |
| 25534621 | Result | Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015 Jan;15(1):30-44. doi: 10.1038/nri3785. |
| 11719079 | Result | Yoshida N, Koga Y, Peng CL, Tanaka E, Kobayashi K. In vivo measurement of the elastic modulus of the human periodontal ligament. Med Eng Phys. 2001 Oct;23(8):567-72. doi: 10.1016/s1350-4533(01)00073-x. |
| 21134234 | Result | Jepsen S, Deschner J, Braun A, Schwarz F, Eberhard J. Calculus removal and the prevention of its formation. Periodontol 2000. 2011 Feb;55(1):167-88. doi: 10.1111/j.1600-0757.2010.00382.x. No abstract available. |
| D004812 |
| Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D003813 | Dentistry |
| D010517 | Periodontics |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D011636 | Public Health Dentistry |