Effect of Dental Pulp Stem Cells and L-PRF After Impacted Third Molar Extraction

Effect of Dental Pulp Stem Cells and L-PRF Placed Into the Extraction Sockets of Impacted Mandibular Third Molars on the Periodontal Status of Adjacent Second Molars: a Split Mouth Randomised Controlled Clinical Trial

The purpose of this study is to compare the clinical and radiographic effectiveness of Leukocyte-Platelet Rich Fibrin (L-PRF) and L-PRF combined with dental pulp stem cell (DPSC) application to the extraction socket of mandibular third molars.

Patients aged between 18 and 30 years, seeking for bilateral impacted LM3 extraction surgeries and meeting eligibility criteria were included to the study. At baseline right and left impacted third molars (LM3s) were randomly assigned to one of the treatment group (L-PRF and L-PRF + DPSC). Baseline and 6th month clinical and radiographic measurements were compared.

Inclusion Criteria:

• Patients aged between 18 and 30 years
• Bilateral impacted LM3 extraction surgeries requirement

Exclusion Criteria:

• Having clinical signs or symptoms of abscess or cellulitis formation
• Having a history of radiotherapy
• Having any systemic diseases interfering with wound healing and/or smokers
• Patients who had been diagnosed as periodontitis
• Patients who had LM2s with caries or restorations that have an unidentifiable cementoenamel junction