Characterization of Neuromuscular Function and Fatigue After Breast Cancer Treated With Adjuvant Chemotherapy (PROTECT-04)

Characterization of Neuromuscular Function and Fatigue After Breast Cancer Treated With Adjuvant Chemotherapy

This is a transversal monocentric study comparing two groups of women (group 1, patient group : patients who have been treated for a breast cancer with taxane-based chemotherapy ; group 2, control group : healthy volunteers). The aim of this study is to evaluate if a difference exists regarding the maximal isometric muscle strength between group 1 and 2.

All subjects will be evaluated a single time during two hours. For patients from group 1 the evaluation should take place within the two weeks that follow the end of adjuvant treatment. There is no specificity regarding evaluation of volunteers from group 2, their evaluation can take place at any time.

Inclusion Criteria :

Group 1 - Patients :

• Give written inform consent
• Age ≥ 18 years
• Affiliate to social security system
• Ability to speak, understand and read French
• Breast cancer, Stage II or III, treated by taxane-based chemotherapy

Group 2 - Control group :

• Give written inform consent
• Age ≥ 18 years
• Affiliate to social security system
• Ability to speak, understand and read French

Exclusion Criteria:

Group 1 - Patients :

• < 18 years old or patients ≥ 18 years old under guardianship, or supervision
• Psychiatric, musculoskeletal or neurologic disorders
• Patients presenting one of the following contraindications to transcranial magnetic stimulation :
• Presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.)
• History of epilepsy
• Brain injury (vascular, traumatic, tumour-induced, infectious or metabolic)
• Women that are pregnant
• Serious or recent heart disease

Group 2 -Control group :

• < 18 years old or patients ≥ 18 years old under guardianship, or supervision
• Psychiatric, musculoskeletal or neurologic disorders
• Pacemaker implantation
• History of cancer
• All known chronic disease
• Subjects presenting one of the following contraindications to transcranial magnetic stimulation :
• Presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.)
• History of epilepsy
• Brain injury (vascular, traumatic, tumour-induced, infectious or metabolic)
• Women that are pregnant
• Serious or recent heart disease