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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A01266-33 | Other Identifier | IDRCB |
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| Name | Class |
|---|---|
| UR 3072 - Mitochondries, Stress oxydant, Protection musculaire | UNKNOWN |
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This is an interventional, prospective and monocentric study. This study includes the evaluation before and after (neo)adjuvant therapy of :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 without trastuzumab | Other |
| |
| Group 2 with trastuzumab | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Microbiopsy sample | Other | before and after chemotherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in vastus lateralis cross-sectional area | Measured from muscle microbiopsy sample | Between Week 18 and 24 after chemotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Alteration of patients body composition | Assessment using bio-impedance analysis | Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy) |
| Alteration of patients strength |
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Inclusion Criteria:
For group 1 without trastuzumab :
For group 2 with trastuzumab :
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut de Cancerologie Strasbourg Europe | Strasbourg | 67033 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34595171 | Result | Mallard J, Hucteau E, Hureau TJ, Pagano AF. Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers. Front Cell Dev Biol. 2021 Sep 14;9:719643. doi: 10.3389/fcell.2021.719643. eCollection 2021. | |
| 35373507 | Result | Mallard J, Hucteau E, Charles AL, Bender L, Baeza C, Pelissie M, Trensz P, Pflumio C, Kalish-Weindling M, Geny B, Schott R, Favret F, Pivot X, Hureau TJ, Pagano AF. Chemotherapy impairs skeletal muscle mitochondrial homeostasis in early breast cancer patients. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1896-1907. doi: 10.1002/jcsm.12991. Epub 2022 Apr 4. |
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| Muscle echography, Maximal strength, Body composition, Quality of life and Physical activity level | Other | before and after chemotherapy |
|
Assessment of maximal isometric muscle strength for knee extensors measured with force sensors.
| Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy) |
| Alteration of patients muscle architecture | Assessment using muscle ultrasonography | Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy) |
| Alteration of patients quality of life | Self-assessment questionnaire Functional Assessment of Cancer Therapy - General (FACT-G) (version 3) | Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy) |
| Evaluation of patient cachexia | Questionnaire Functional Assessment of Anorexia/Cachexia Therapy (FAACT) (version 4) | Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy) |
| 36094434 | Result | Mallard J, Hucteau E, Bender L, Charlot A, Debrut L, Pflumio C, Trensz P, Schott R, Favret F, Pivot X, Hureau TJ, Pagano AF. Development of skeletal muscle atrophy and intermuscular adipose tissue in patients with early breast cancer treated with chemotherapy. Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C1325-C1332. doi: 10.1152/ajpcell.00373.2022. Epub 2022 Sep 12. |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D001823 | Body Composition |
| D011788 | Quality of Life |
| ID | Term |
|---|---|
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D008660 | Metabolism |
| D001824 | Body Constitution |
| D010829 | Physiological Phenomena |
| D006304 | Health Status |
| D003710 | Demography |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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