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This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS | Active Comparator | 40 minutes of 2mA intensity direct current stimulation |
|
| sham tDCS | Sham Comparator | 40 minutes of 0mA intensity. the session starts with a ramp up to 2mA, but machine is switched off after 2 minutes of stimulation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anodal tDCS | Device | 40 minutes of 2mA intensity direct current stimulation was delivered over both the right and left motor cortex simultaneously |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fatigue Severity Scale - 7 | a questionnaire based fatigue scale | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Resting Motor Threshold | This is a measure of cortical excitability as measured by transcranial magnetic stimulation | 1 day |
| Input-output curves | This is a measure of cortical recruitment as measured by transcranial magnetic stimulation |
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Inclusion Criteria:
Diagnosed with stroke at least 3 months post-stroke
Exclusion Criteria:
Other neurological conditions on Anti-depressants severe motor impairment (affected hand grip <60% unaffected hand) severe cognitive impairment (unable to follow instructions, or give informed consent) scored >11 in the depression sub-section of HADS questionnaire contraindications for TMS or tES
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 33 Queen Square, Institute of Neurology, UCL | London | WC1N 3BG | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33598767 | Derived | De Doncker W, Ondobaka S, Kuppuswamy A. Effect of transcranial direct current stimulation on post-stroke fatigue. J Neurol. 2021 Aug;268(8):2831-2842. doi: 10.1007/s00415-021-10442-8. Epub 2021 Feb 17. |
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| ID | Term |
|---|---|
| D005221 | Fatigue |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| sham tDCS | Device | The stimulator was switched off after 2 minutes of stimulation. |
|
| 1 day |
| Perceived effort - Explicit | A VAS scale associated with a grip task | 1 day |
| Perceived effort - Implicit | A novel line length estimation task | 1 day |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |