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In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
Then determine the most appropriate combination of positive end-tidal pressure and tidal volume.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Evaluation of intratidal compliance | Experimental | When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Changes in positive end-expiratory pressure and tidal volume | Other | When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order. Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg |
| Measure | Description | Time Frame |
|---|---|---|
| Intratidal compliance profiles in each ventilator settings | The investigators will determine Intratidal compliance profile using the changes in compliance over time --> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high. | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory compliance | ml cmH2O-1 | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) |
| Driving pressure | cmH2O |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34686309 | Derived | Lee JH, Kang P, Song IS, Ji SH, Lee HC, Jang YE, Kim EH, Kim HS, Kim JT. Determining optimal positive end-expiratory pressure and tidal volume in children by intratidal compliance: a prospective observational study. Br J Anaesth. 2022 Jan;128(1):214-221. doi: 10.1016/j.bja.2021.09.024. Epub 2021 Oct 20. |
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|
| During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) |
| Blood pressure | mmHg | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D013990 | Tidal Volume |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
| D007320 | Inspiratory Capacity |
| D014797 | Vital Capacity |
| D014109 | Total Lung Capacity |
| D008176 | Lung Volume Measurements |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012143 | Respiratory Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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