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The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in pediatric patients. The hypothesis is that application of low tidal volume, intermittent alveolar recruitment and adequate positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional ventilation group | Placebo Comparator | Mechanical ventilation is maintained with tidal volume (TV) of 10 ml/kg without PEEP during two-lung ventilation and TV of 8 ml/kg without PEEP during one-lung ventilation. Alveolar recruitment is performed 3 times; after intubation, before one-lung ventilation and after lung resection. |
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| Lung protective ventilation group | Active Comparator | Mechanical ventilation is maintained with tidal volume (TV) of 6 ml/kg with PEEP 6 cmH2O during two-lung ventilation and TV of 4 ml/kg PEEP 6 cmH2O during one-lung ventilation. Alveolar recruitment is performed 3 times; after intubation, before one-lung ventilation and after lung resection. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lung protective ventilation | Procedure | TV 4 ml/kg during one lung ventilation and 6 ml/kg during two-lung ventilation with PEEP of 6 cmH2O |
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| Measure | Description | Time Frame |
|---|---|---|
| The number of patients with pulmonary complication | The number of patients with pulmonary complication including atelectasis, pulmonary infiltration, pulmonary edema, pulmonary infection, pleural effusion and pulmonary embolism | up to postoperative 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| The number of patients with desaturation | The number of patients with desaturation (SpO2 < 90%) | During surgery |
| The number of patients with extrapulmonary complication | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jin-Tae Kim, PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul national university hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30916035 | Derived | Lee JH, Bae JI, Jang YE, Kim EH, Kim HS, Kim JT. Lung protective ventilation during pulmonary resection in children: a prospective, single-centre, randomised controlled trial. Br J Anaesth. 2019 May;122(5):692-701. doi: 10.1016/j.bja.2019.02.013. Epub 2019 Mar 8. |
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| Conventional ventilation | Procedure | TV 8 ml/kg during one lung ventilation and 10 ml/kg during two-lung ventilation without PEEP |
|
| Mean duration of mechanical ventilation | through study completion, an average of 1 year |
| Mean duration of ICU stay | through study completion, an average of 1 year |