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Pain in knee osteoarthritis (OA) represents increased pain intensity due to peripheral and central sensitivity. Pressure pain threshold (PPT) is a widely applied technique for measuring the magnitude of peripheral and central sensitivity in knee OA. Despite several manual therapy techniques has been proven to increase PPT in knee OA, the effect of end-range mobilization on the time curve of PPT has not been evaluated so far in knee OA. The aim of this study was to investigate the effect of end-range mobilization on the time curve of PPT and some function-related measures in knee OA.
Knee osteoarthritis (OA) is the most common form of arthritis leading to a major disability worldwide. Although many mechanisms may contribute to knee pain severity, the patient-reported hyperalgesia can be attributed to peripheral and central sensitivity in knee OA. Amongst quantitative sensory testing methods, pressure pain threshold (PPT) measurement is a simple and commonly applied method for measuring somatosensory function in musculoskeletal disorders, just as in knee OA. Many trials have presented lower PPT in knee OA compared to healthy controls underlining the presence of peripheral and central sensitivity.
The different joint-based mobilization techniques may not only alleviate pain, but also increase pain tolerance to the locally applied mechanical pressure. Positive results of these techniques on increase of PPT has been reported in knee OA; however, the time curve of PPT has not evaluated so far in knee OA. Therefore, the aim of this study was to investigate the effect of end-range mobilization on the time curve of PPT and some function-related measures in knee OA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| End-range mobilization | Experimental | End-range mobilization performed in end-position of the tibiofemoral joints' flexion and extension for 2*3 min |
|
| Non end-range mobilization | Active Comparator | Non end-range mobilization performed in tibiofemoral joints' loose position |
|
| Placebo | Placebo Comparator | Hands-on treatment technique performed in end-range of the tibiofemoral joints' flexion and extension for 2*3 min |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| End-range mobilization | Biological | End-range mobilization performed in end-range of the tibiofemoral joints' flexion and extension |
|
| Measure | Description | Time Frame |
|---|---|---|
| PPT of the knee | pressure pain threshold of the knee | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| PPT of the m. Extensor Carpi Radialis Longus (ECRL) | pressure pain threshold at the ECRL | 30 minutes |
| PPT of the m. Extensor Carpi Radialis Longus (ECRL) | pressure pain threshold at the ECRL |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Miklós Pozsgai | Harkány Thermal Rehabilitation Centre | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harkány Thermal Rehabilitation Centre | Harkány | Please Select | 7815 | Hungary | ||
| Miklós Pozsgai |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16714085 | Background | Kidd BL. Osteoarthritis and joint pain. Pain. 2006 Jul;123(1-2):6-9. doi: 10.1016/j.pain.2006.04.009. Epub 2006 May 22. No abstract available. | |
| 20346403 | Background | Wise BL, Niu J, Zhang Y, Wang N, Jordan JM, Choy E, Hunter DJ. Psychological factors and their relation to osteoarthritis pain. Osteoarthritis Cartilage. 2010 Jul;18(7):883-7. doi: 10.1016/j.joca.2009.11.016. Epub 2010 Mar 24. |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Non end-range mobilization | Biological | Non end-range mobilization performed in tibiofemoral joints' loose position |
|
| Placebo | Biological | Hands-on technique performed in end-range of the tibiofemoral joints' flexion and extension |
|
| every 2nd day for the following 6-day |
| Timed Up and Go test | Timed Up and Go test measuring functional capacity | 30 minutes |
| Timed Up and Go test | Timed Up and Go test measuring functional capacity | every 2nd day for the following 6-day |
| Strength of passive tension of the knee | Strength of passive tension of the knee measured in Newton at the beginning of pain | 30 minutes |
| Strength of passive tension of the knee | Strength of passive tension of the knee measured in Newton at the beginning of pain | every 2nd day for the following 6-day |
| Pressure Pain Threshold measurement of the knee | pressure pain threshold measurement of the knee via hand-held algometer | every 2nd day for the following 6-day |
| Harkány |
| Please Select |
| 7815 |
| Hungary |
| 11427321 | Background | Bajaj P, Bajaj P, Graven-Nielsen T, Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain. 2001 Aug;93(2):107-114. doi: 10.1016/S0304-3959(01)00300-1. |
| 18821657 | Background | Imamura M, Imamura ST, Kaziyama HH, Targino RA, Hsing WT, de Souza LP, Cutait MM, Fregni F, Camanho GL. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum. 2008 Oct 15;59(10):1424-31. doi: 10.1002/art.24120. |
| 22120461 | Background | Wylde V, Palmer S, Learmonth ID, Dieppe P. Somatosensory abnormalities in knee OA. Rheumatology (Oxford). 2012 Mar;51(3):535-43. doi: 10.1093/rheumatology/ker343. Epub 2011 Nov 24. |
| 14622705 | Background | Hendiani JA, Westlund KN, Lawand N, Goel N, Lisse J, McNearney T. Mechanical sensation and pain thresholds in patients with chronic arthropathies. J Pain. 2003 May;4(4):203-11. doi: 10.1016/s1526-5900(03)00557-1. |
| 29308949 | Background | Kaya Mutlu E, Ercin E, Razak Ozdincler A, Ones N. A comparison of two manual physical therapy approaches and electrotherapy modalities for patients with knee osteoarthritis: A randomized three arm clinical trial. Physiother Theory Pract. 2018 Aug;34(8):600-612. doi: 10.1080/09593985.2018.1423591. Epub 2018 Jan 8. |
| 25440203 | Background | Khademi-Kalantari K, Mahmoodi Aghdam S, Akbarzadeh Baghban A, Rezayi M, Rahimi A, Naimee S. Effects of non-surgical joint distraction in the treatment of severe knee osteoarthritis. J Bodyw Mov Ther. 2014 Oct;18(4):533-9. doi: 10.1016/j.jbmt.2013.12.001. Epub 2013 Dec 11. |
| D012216 |
| Rheumatic Diseases |