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The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, the effect of conservative therapy has also been proven in the increase of pain threshold in KOA. However, no study has investigated the effect of these interventions combined till date in KOA.
The aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in KOA.
The positive effect of different manual mobilizations have been proven in the management of knee osteoarthritis (KOA). Pressure pain threshold, as a measure of somatosensory function, is a well-applied measurement technique for the pain perception in KOA. The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, few studies has revealed the effect of conservative therapy as an effective intervention in the increase of pain threshold. However, no study has investigated the effect of these interventions combined till date in KOA, which could give a long-lasting effect in the decrease of sensitization in KOA.
Therefore, the aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in KOA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| End-range mobilization | Experimental | End-range mobilization performed in end-position of the knee joint |
|
| Non end-range mobilization | Experimental | Non end-range mobilization performed in loose-packed position of the knee joint |
|
| Control | Placebo Comparator | Sham technique performed in loose-packed position of the knee joint |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| end-range mobilization | Procedure | accessory technique applied on the tibiofemoral joint with the aim of increasing extensibility of the periarticular tissues |
|
| Measure | Description | Time Frame |
|---|---|---|
| change of peripheral sensitivity | peripheral sensitivity (pressure pain threshold) assessed at the local knee | following 3-week rehabilitation |
| change of peripheral sensitivity | peripheral sensitivity (pressure pain threshold) assessed at the local knee | following 3-month |
| Measure | Description | Time Frame |
|---|---|---|
| change of central sensitivity | central sensitivity (pressure pain threshold) assessed at the ipsilateral m. extensor carpi radialis longus | following 3-week rehabilitation |
| change of central sensitivity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Miklós Pozsgai, MSc | Zsigmondy Vilmos Spa and Balneological Hospital of Harkány | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Miklós Pozsgai | Harkány | Please Select | 7815 | Hungary |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24462672 | Background | McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88. doi: 10.1016/j.joca.2014.01.003. Epub 2014 Jan 24. | |
| 11427321 |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Non end-range mobilization | Procedure | accessory technique applied on the tibiofemoral joint with the aim of alleviating pain |
|
| Control | Procedure | hands-on cutaneous technique |
|
central sensitivity (pressure pain threshold) assessed at the ipsilateral m. extensor carpi radialis longus
| following 3-month |
| change of general pain intensity | general pain intensity from the previous week using the Visual Analogue Scale | following 3-week rehabilitation |
| change of general pain intensity | general pain intensity from the previous week using the Visual Analogue Scale | following 3-month |
| change of Timed Up and Go test | short test for measuring physical performance | following 3-week rehabilitation |
| change of Timed Up and Go test | short test for measuring physical performance | following 3-month |
| change of pain intensity during physical performance | pain intensity measured during the previously mentioned physical performance test using the 0-10 Numerating Pain Rating Scale, where 0 indicate no pain and 10 indicate worst imaginable pain | following 3-week rehabilitation |
| change of pain during physical performance | pain intensity measured during the previously mentioned physical performance test using the 0-10 Numerating Pain Rating Scale, where 0 indicate no pain and 10 indicate worst imaginable pain | following 3-month |
| degree of knee flexion during passive movement at the onset of knee pain | measurement of degree of knee flexion during passive movement at the onset of knee pain | following 3-week rehabilitation |
| degree of knee flexion during passive movement at the onset of knee pain | measurement of degree of knee flexion during passive movement at the onset of knee pain | following 3-month |
| strength of resistance of passive knee flexion at the onset of knee pain | measurement of strength of resistance arising from the anterior located tissues around the knee during passive knee flexion at the onset of pain | following 3-week rehabilitation |
| strength of resistance of passive knee flexion at the onset of knee pain | measurement of strength of resistance arising from the anterior located tissues around the knee during passive knee flexion at the onset of pain | following 3-month |
| Bajaj P, Bajaj P, Graven-Nielsen T, Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain. 2001 Aug;93(2):107-114. doi: 10.1016/S0304-3959(01)00300-1. |
| 18821657 | Background | Imamura M, Imamura ST, Kaziyama HH, Targino RA, Hsing WT, de Souza LP, Cutait MM, Fregni F, Camanho GL. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum. 2008 Oct 15;59(10):1424-31. doi: 10.1002/art.24120. |
| 16777467 | Background | Moss P, Sluka K, Wright A. The initial effects of knee joint mobilization on osteoarthritic hyperalgesia. Man Ther. 2007 May;12(2):109-18. doi: 10.1016/j.math.2006.02.009. Epub 2006 Jun 13. |
| D012216 |
| Rheumatic Diseases |