The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

The Effect of Arterial Oxygen Levels on Thiol Disulfide Homeostasis and Ischemia Modified Albumin in Coronary Artery Bypass Surgery

We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Inclusion Criteria:

• patient scheduled for cardiac surgery
• ASA>3
• Aged 18-75 years

Exclusion Criteria:

• those with valvular disease
• EF<%40
• BMI>40 kg/m2
• presence of arrhythmia that impairs hemodynamics
• previous history of cerebrovascular
• diagnosed with end-stage organ failure