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We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.
Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | Group 1: Pressure of arterial oxygen> 200 mmHg during the coronary surgery |
| |
| group 2 | Group 2: Pressure of arterial oxygen<200 mmHg and >80 mmHg during the coronary surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| taken venous sample | Diagnostic Test | Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures. |
|
| Measure | Description | Time Frame |
|---|---|---|
| assessment of oxidative damage | To measure the degree of oxidative damage in the patient's blood at different oxygen values used in cardiac bypass surgeries with thiol disulfide homeostasis and ischemia-modified albumin at times determined. | 48 hours after operation |
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Inclusion Criteria:
Exclusion Criteria:
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128 patients scheduled for cardiac surgery
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| Name | Affiliation | Role |
|---|---|---|
| Ümran K Karaca, md | Bursa Yuksek Ihtisas Training and Research Hospital | Principal Investigator |
| Tuğba O Onur, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Şeyda Ö Özgünay, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Filiz A Ata, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Canan Y Yılmaz, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Şermin E Eminoğlu, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Halil Erkan S Sayan, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Yasemin Ü Üstündağ, MD | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
| Anıl O Onur, MD | Bursa Yuksek Ihtisas Training and Research Hospital |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital | Bursa | 60160 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Study Director |