Effects of Hyperoxia on Open Heart Surgery

Effects of Hyperoxia on Oxidative Stress in Patients Undergoing Open Heart Surgery

Patients undergoing Open Cardiac Surgery will be randomized into two groups. Group I will be ventilated with 40% Fio2 during induction, surgery and in Postoperative care unit. Group II will be ventilated with 100% Fio2 during induction and with 60-70% ( determined according to the arterial blood gas sample results) during surgery and in Postoperative care unit.

Hemodynamic parameters ( systolic arterial pressure, diastolic arterial pressure, heart rate ), Arterial blood gas samples ( PaO2, PaCO2, pH, Oxygen saturation, Lactate), and pre and post cardiopulmonary bypass Superoxide dismutase and malonyl aldehyde levels.

Inclusion Criteria:

• ASA II-III
• Patients with EF higher than 50%.
• patients undergoing elective open heart surgery on pump ( CABG, Valve Replacement)

Exclusion Criteria:

• patients with Diabetes Mellitus
• patients with COPD
• Patients with Cerebral Vascular Disease
• Patients with hypoxia in Arterial blood gas samples ( PaO2 lower than 80 mmHg) and hypercarbia (PaCO2 higher than 45 mmHg)