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Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 40% oxygen | Active Comparator | Patients in this group will be ventilated with fraction of inspired oxygen 40% during the surgery. |
|
| 80% oxygen | Active Comparator | Patients in this group will be ventilated with a fraction of inspired oxygen 80% during the surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fraction of inspired oxygen 40% | Other |
| ||
| Fraction of inspired oxygen 80% |
| Measure | Description | Time Frame |
|---|---|---|
| oxidant and antioxidant response | As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamics | The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics. | 4 hours |
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Inclusion Criteria:
Exclusion Criteria:
Patients will be recruited through general surgery service of our hospital
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| Name | Affiliation | Role |
|---|---|---|
| Yalim Dikmen, Prof. | Cerrahpasa Medical Faculty Chairman of Intensive Care Department | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department | Istanbul | Fatih | 34400 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15055896 | Background | Koksal GM, Sayilgan C, Aydin S, Uzun H, Oz H. The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy. Eur J Anaesthesiol. 2004 Mar;21(3):217-20. doi: 10.1017/s0265021504003102. |
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| Other |
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