Pre-emptive Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section

The Effects Of Pre-emptive Single Oral Dose Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section

There is exaggerated neuroendocrine stress response to laryngoscopy and endotracheal intubation during the Induction to anesthesia-delivery (I-D) period under light anesthesia. Mechanical stimulation of laryngeal proprioceptors elicits increased secretion of cortisol and catecholamine with subsequent elevation of blood pressure from 40 to 50 % and heart rate up to 20 % during direct laryngoscopy and endotracheal intubation

The sample size was calculated using OPEN EPI program assuming that the mean visual analogue scale anxiety score was 49.3±14.1 among oral pregabalin group and was 58.6± 14.4 among Placebo group (8) so at power of study 80% confidence interval 95%, the sample size was calculated to be 74 cases (37in each group

Inclusion Criteria:

• Age: 21-38 years old.
• Pregnant Female with a singleton fetus of at least 36 weeks of gestation.
• American Society of Anesthesiologist Physical status: 1& II.
• Body Mass Index (BMI) (25-30kg/m²).
• Type of operations: elective caesarean section under general anesthesia.
• Written informed consent from the parturient.

Exclusion Criteria:

• Altered mental state.
• Women with known history of allergy to pregabalin.
• Women with uncontrolled diabetes mellitus, bleeding, coagulation disorders, Hepatic, renal, Cardiovascular, respiratory disease and neuropsychiatric disorders.
• Patients receiving anticonvulsants, antidepressants.
• Pregnancy induced hypertension, intrauterine growth restriction or fetal compromise