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| Name | Class |
|---|---|
| University of Bern | OTHER |
| University of Oxford | OTHER |
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The aim of this project is to measure behavioural disorders in Parkinson's disease (PD) patients in a more objective way, in order to facilitate the detection of those symptoms and improve the treatment of non-motor symptoms in Parkinson's disease.
Apathy and impulse control disorders (ICDs) are frequent non-motor symptoms of PD and negatively affect the quality of life of patients. Although healthcare professionals have begun to understand the extent of the problem faced by those suffering apathy or ICDs, accurate diagnosis is still difficult, as behavioural symptoms are often multidimensional, develop gradually over the course of months and clinical staff have to rely on the self-report of the patient or the report of a family member to assess them. To overcome this issue, the investigators aim to use information and communication technologies to measure apathy and hyperdopaminergic behaviours in PD patients with STN-DBS in an objective way, with the ultimate goal of improving the management of PD patients with STN-DBS.
To do so, the investigators will use three computer-based tasks that measure effort-based decision making and emotion processing in PD patients, and assess motor, cognitive and neuropsychiatric symptoms in parallel with scales and tests. In some select patients, motor symptoms and activity patterns will be monitored with an in-home sensor system before and after deep brain stimulation STN-DBS, and the above mentioned procedures will be repeated 4 months after STN-DBS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD patients with apathy | PD patients with apathy according to the diagnostic criteria by Robert et al. 2018 | ||
| PD patients with impulse control disorder | PD patients with a) at least one item >2 or b) at least two items >1 on the hyperdopaminergic subscale of the Ardouin Scale of Behaviour in Parkinson's Disease | ||
| PD patients without any relevant neuropsychiatric symptoms | PD patients with a score <2 on each item of the Ardouin Scale of Behaviour in Parkinson's Disease |
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| Measure | Description | Time Frame |
|---|---|---|
| Performance in an effort-based decision making task (Apple Tree Paradigm) | Decision (yes/no) | Visit 1 (only visit for most patients; for DBS patients 1-3 months before DBS-surgery) |
| Performance in an effort-based decision making task (Apple Tree Paradigm) | Decision (yes/no) | Visit 2 (only for DBS patients; 4-6 months after DBS-surgery) |
| Performance in an emotion processing task | Pupil diameter (in mm) | Visit 1 (only visit for most patients; for DBS patients 1-3 months before DBS-surgery) |
| Performance in an emotion processing task | Pupil diameter (in mm) | Visit 2 (only for DBS patients; 4-6 months after DBS-surgery) |
| Change in overall activity from Baseline to 4 months after DBS-surgery | Changes in overall activity patterns related to motivated behaviours (measured in minutes per day) will be deducted from collected from in-home sensor data using signal processing and machine learning algorithms | In-home sensor measurements will be collected from 1-3 months before DBS-surgery and 4 months after DBS-surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with idiopathic Parkinson's disease, treated at the movement disorders clinic in the University Hospital of Bern, Switzerland.
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| Name | Affiliation | Role |
|---|---|---|
| Paul Krack, MD | Insel Gruppe AG, University Hospital Bern | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Insel Gruppe AG University Hospital of Bern | Bern | CH-3010 | Switzerland |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D001523 | Mental Disorders |
| D053609 | Lethargy |
| D007174 | Disruptive, Impulse Control, and Conduct Disorders |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |