Impact of Subthalamic Nucleus Deep Brain Stimulation on COGnitive and PSYchiatric Symptoms in Parkinson's Disease | NCT07777419 | Trialant

Not yet recruitingInterventionalNot ApplicableUpdated Aug 20, 2026

Impact of Subthalamic Nucleus Deep Brain Stimulation on COGnitive and PSYchiatric Symptoms in Parkinson's Disease

Overview

Key facts that identify this study and show where it stands today.

What the study is about and why it is being run, in the researchers' own words.

Official Title: Impact of Subthalamic Nucleus Deep Brain Stimulation on COGnitive and PSYchiatric Symptoms in Parkinson's Disease
Brief Summary: With this study, the investigators want to investigate how deep brain stimulation (DBS) affects various cognitive and psychiatric symptoms of Parkinson's disease (PD). In particular, they will examine whether stimulation of the left hemisphere has a different effect than stimulation of the right hemisphere on cognitive and psychiatric symptoms.
Detailed Description: Previous studies have shown that motor symptoms improve with DBS in PD. It is also know that DBS can have an effect on cognitive and psychiatric symptoms. However, in the studies completed so far, it has not yet been possible to conclusively assess the exact effect of the stimulation itself on various cognitive and psychiatric symptoms. In particular, there is currently no data on how the precise localization of stimulation at the target site-the subthalamic nucleus (STN)-affects cognitive and psychiatric symptoms. It is not yet clear whether electrical stimulation of the right subthalamic nucleus has different effects on cognition and mood than stimulation of the left subthalamic nucleus. The aim of this study is to investigate whether DBS of the left hemisphere affects cognition and mood differently than DBS of the right hemisphere.

The medical conditions and diseases this study investigates.

The treatments and procedures being evaluated in this study.

Who can join this study and the criteria used to decide.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Diagnosed with Parkinson's disease

Treated with subthalamic nucleus deep brain stimulation (STN-DBS)

For part I: General research consent for the analysis of routine clinical data

For part II of the study: ability to provide informed consent

native German or French speaker

Montreal Cognitive Assessment with score ≥ 20

Exclusion Criteria:

Atypical Parkinsonism

Other disease affecting the brain (e.g. Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, non-provoked epilepsy, brain tumour, etc.)

Haemorrhage during implantation of STN-DBS, which resulted in permanent cognitive or physical impairment

Schizophrenia, ongoing substance abuse, bipolar disorder or autism

For part II: Severe depressive disorder and/or suicidality

Insufficient quality or lack of brain imaging data pre and/or post STN-DBS

How the study is designed and how its participant groups are organized.

The people to reach with questions about this study or how to join it.

Deborah Amstutz, PhDContact

deborah.amstutz@insel.ch+41 31 66 4 05 67

Where the study is run and whether each site is currently recruiting.

University Hospital Inselspital, Berne

Bern, 3010, Switzerland

The organizations and people involved in this study.

Other registered studies that closely resemble this one.