Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Multiple Myeloma (MYELOMEFRAGIQUANTI)

Assessment of Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Patients With Multiple Myeloma

Multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. Invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction. The main objective is to assess the correlation between vertebral bone marrow fat fraction and bone fragility represented by a severity score of vertebral fractures. The secondary objective is to assess the correlation with clinical and biological prognostic factors and scores..

Patients treated with vertebroplasty will be included during the period of the study, retrospectively or prospectively.

Mains collected data are represented by :

• Bone marrow fat fraction determined by MRI
• Severity score for vertebral fractures
• Clinical prognostic factors
• Biological prognostic factors
• Clinico-biological scores Descriptive statistics and correlation analyses will be performed between the measured parameters.

Inclusion Criteria:

• Patients followed for multiple myelomas in the Lariboisière/Saint-Louis/Fernand-Widal hospital group
• vertebral fractures treated by vertebroplasty from January 2017 to December 2021
• recent clinical and biological data available at the time of imaging and fracture events

Exclusion Criteria:

• Factors modifying the bone marrow fat fraction (extensive radiotherapy)
• Lack of recent clinical or biological data compared to imaging examinations