Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women

Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women: a Case-control Study

The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.

Inclusion Criteria:

• post-menopausal women : 50-90 years old
• Group 1 (cases) : occurence of incident major osteoporotic fracture less than 12 months
• Group 2 (controls) : no history of fragility fracture

Exclusion Criteria:

• Implants that are contraindicated for the magnetic resonance (MR) examination.
• Implants that might create a health risk or other problem during an MR exam include: 1) cardiac pacemaker or implantable defibrillator, 2) catheter that has metal components that may pose a risk of a burn injury, 3) a ferromagnetic metal clip placed to prevent bleeding from an intracranial aneurysm, 4) an implanted medication pump (such as that used to deliver insulin or a pain-relieving drug), and 5) a cochlear implant.
• body mass index [BMI] >38 kg/m2, weight >140 kg
• Disease or current use of medications known to affect bone density, including oral glucocorticoids, treatments for osteoporosis (bisphosphonates, raloxifene, calcitonin, or PTH), hormone therapy.
• Chronic kidney disease with DFG <30 ml/mn