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| Name | Class |
|---|---|
| National Research Council of Thailand | OTHER_GOV |
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This research compare the effects of low carbohydrate intake and consumption of 3 eggs per day, and low energy diet on diabetes control and biomarkers of CVD in obese people.
This research study examines the effects of changes in weight, metabolism of glucose and cholesterol in the blood through diet and behavior modification. The main objective of this study was to compare the effects of low carbohydrate intake and consumption of 3 eggs per day, and low energy diet on diabetes control and biomarkers of CVD in obese people. In addition, HDL quantity and size as well as HDL function was compared between the group who ate the whole egg and the group who did not eat the yolk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Yolk ketogenic diet | Experimental | consume carbohydrate < 10% and 3 whole eggs supplement per day in 12 weeks |
|
| White ketogenic diet | Experimental | consume carbohydrate < 10% and 6 white eggs supplement per day in 12 weeks |
|
| Control group | Active Comparator | decrease consumption of diet from typical (decreased energy 20%) but consume carbohydrate in normal level |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diet intervention | Behavioral | Volunteers will be instructed on dietary recommendation throughout the research program to achieve a stable daily energy intake. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in weight following dietary intervention | weight (kg) analysis | Baseline and after 12 weeks |
| Changes in body mass index following dietary intervention | body mass index (kg/m^2) analysis | Baseline and after 12 weeks |
| Changes in waist circumference following dietary intervention | waist circumference (cm) analysis | Baseline and after 12 weeks |
| Changes in lipid profiles concentration following dietary intervention | Triglycerides (mg/dl), Cholesterol (mg/dl), HDL-cholesterol (mg/dl) and LDL-cholesterol (mg/dl) concentration analysis | Baseline and after 12 weeks |
| Changes in blood glucose and insulin concentration following dietary intervention | HbA1C (%), glucose (mg/dl) and insulin (mg/dl) concentration analysis | Baseline and after 12 weeks |
| Changes in betahydroxybutirate concentration following dietary intervention | betahydroxybutirate (mmol/L) concentration analysis | Baseline and after 12 weeks |
| Changes in electrolytes concentration following dietary intervention | Na+ (mg/dl), K+ (mg/dl), Cl- (mg/dl) and HCO3- (mg/dl) concentration analysis | Baseline and after 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in blood pressure | systolic and diastolic blood pressure (mmHg) | Baseline and after 12 weeks |
| Changes in fasting leptin levels | leptin (mg/dl) concentration analysis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Korapat Mayurasakorn, MD. | Doctor in Family Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Siriraj Hospital, Mahidol University | Bangkok Noi | Bangkok | 10700 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39245182 | Derived | Pinsawas B, Surawit A, Mongkolsucharitkul P, Pongkunakorn T, Suta S, Manosan T, Ophakas S, Pumeiam S, Sranacharoenpong K, Mayurasakorn K. Asian Low-Carbohydrate Diet with Increased Whole Egg Consumption Improves Metabolic Outcomes in Metabolic Syndrome: A 52-Week Intervention Study. J Nutr. 2024 Nov;154(11):3331-3345. doi: 10.1016/j.tjnut.2024.08.027. Epub 2024 Sep 7. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D003920 | Diabetes Mellitus |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| Changes in physical activity | physical activity (MET-minutes/week) collect data by using questionnaires | Baseline and after 12 weeks |
| Change from baseline Glycemia at 180 minutes | glucose (mg/dl) | Minutes after intake of 75 g glucose: 0, 30, 60, 90, 120, 180 |
| Change from baseline Insulin at 180 minutes | insulin (μU/ml) | Minutes after intake of 75 g glucose: 0, 30, 60, 90, 120, 180 |
| Baseline and after 12 weeks |
| Changes in energy intake following dietary intervention | energy (kcal) | Baseline and after 12 weeks |
| Changes in carbohydrate following dietary intervention | carbohydrate (g) | Baseline and after 12 weeks |
| Changes in protein intake following dietary intervention | protein (g) | Baseline and after 12 weeks |
| Changes in fat intake following dietary intervention | fat (g) | Baseline and after 12 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |