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This study evaluates the effect of a cognitive remediation program on neurocognitive, social cognitive and metacognitive functions designed for patients living with a schizophrenia spectrum disorder.
Evaluation of the specific therapeutic efficacy of the ecological cognitive remediation program for schizophrenia spectrum disorder [ECo-Sz] on neurocognitive deficits, social cognition deficits and metacognition deficits of patients with a schizophrenia spectrum disorder.
In this double-blind (patients, outcomes assessors) controlled randomized trial the investigators compare patients receiving Ecological Cognitive training program for schizophrenia spectrum disorder [ECo-Sz] to patients benefiting from recovery-oriented therapy [ThOR]. Patients are treated for two months and monitored for four months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ecological Cognitive training program for schizophrenia spectrum disorder [ECo-Sz] | Experimental | To inform the patient about cognitive impairments and their repercussions ; to train the patient in problem-solving skills through exercices ; to implement strategies in daily life. Duration : two month. Frequency : Two one hour individual sessions and one hour of at-home training per week. Modalities : pen and papers exercices (tools, token, cards, maps and chessboard). Modules : Psychoeducation, Attention, Memory, Executive functions, Social cognition and metacognition, Functional impairments |
|
| [THoR] Recovery-Oriented Therapy | Active Comparator | Individual psychotherapy sessions focussing on autonomy in daily life, management of mood disorders' and functional impact, social skills, motivation and the regulation of sleep and daily activities |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [Eco-Sz] Ecological Cognitive training program for schizophrenia spectrum disorder | Other | The first group will have [Eco-Sz] Ecological Cognitive training program for schizophrenia spectrum disorder |
| Measure | Description | Time Frame |
|---|---|---|
| STROOP | Interference score | pre-inclusion |
| TMTB | Trail Making Test | pre-inclusion |
| Litteral score of Verbal fluences | Litteral score of Verbal fluences | pre-inclusion |
| GO/NOGO | cognitive control score | pre-inclusion |
| tower of Hanoi | Tower planning total score from tower of Hanoi | pre-inclusion |
| Matrix test (WAIS-IV) | The perceptual reasoning score of the Matrix test. | pre-inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Mini-500 | (Entretien structuré Neuropsychiatrique International | pre-inclusion |
| CTQ | Childhood Trauma Questionnaire - minimum value = 28 - maximum value = 112 |
| Measure | Description | Time Frame |
|---|---|---|
| FAUX-PAS Test | A test assessing first and second degree theory of mind through short stories and pictures involved two or three characters - minimum value = 0 - maximum value = 60 | First week |
| FAUX-PAS Test |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dominique JANUEL, MBBS | Contact | 0143093232 | d.januel@epsve.fr |
| Name | Affiliation | Role |
|---|---|---|
| Clémence ISAAC, PHD | URC EPS Ville Evrard | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ch Ville Evrard | Recruiting | Neuilly-sur-Marne | 93330 | France |
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The first group is about cognitive remediation therapy (ECo-Sz). The second group is about recovery oriented therapy (ThOR).
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|
| Recovery-Oriented Therapy | Other | The second group will have [THoR] Recovery-Oriented Therapy |
|
|
| pre-inclusion |
| PANSS | Positive and Negative Syndrome Scale - minimum value = 30 - maximum value = 210 | pre-inclusion |
| EESEP | Self-Efficacity Rating Scale - minimum value = 21 - maximum value = 105 | Eighteen week |
| EESEP | Self-Efficacity Rating Scale - minimum value = 21 - maximum value = 105 | Twenty six week |
| ERF | Functional Impact Scale - minimum value = 5 - maximum value = 35 | First week |
| ERF | Functional Impact Scale - minimum value = 5 - maximum value = 35 | Ten week |
| ERF | Functional Impact Scale - minimum value = 5 - maximum value = 35 | Eighteen week |
| ERF | Functional Impact Scale - minimum value = 5 - maximum value = 35 | Twenty six week |
| ERF-CS | Functional Impact Scale for Social Cognition disorders- minimum value = 4 - maximum value = 20 | First week |
| ERF-CS | Functional Impact Scale for Social Cognition disorders- minimum value = 4 - maximum value = 20 | Ten week |
| ERF-CS | Functional Impact Scale for Social Cognition disorders- minimum value = 4 - maximum value = 20 | Eighteen week |
| ERF-CS | Functional Impact Scale for Social Cognition disorders- minimum value = 4 - maximum value = 20 | Twenty six week |
| MCQ-30 | Short French Meta-Cognitions Questionnaire - minimum value = 30 - maximum value = 120 | First week |
| MCQ-30 | Short French Meta-Cognitions Questionnaire - minimum value = 30 - maximum value = 120 | Ten week |
| MCQ-30 | Short French Meta-Cognitions Questionnaire - minimum value = 30 - maximum value = 120 | Eighteen week |
| MCQ-30 | Short French Meta-Cognitions Questionnaire - minimum value = 30 - maximum value = 120 | Twenty six week |
| QFS | Social Functioning Questionnaire - no minimum or maximum value | First week |
| QFS | Social Functioning Questionnaire - no minimum or maximum value | Ten week |
| QFS | Social Functioning Questionnaire - no minimum or maximum value | Eighteen week |
| QFS | Social Functioning Questionnaire - no minimum or maximum value | Twenty six week |
| SAIQ | Self-Appraisal of Illness Questionnaire - minimum value = 17- maximum value = 68 | First week |
| SAIQ | Self-Appraisal of Illness Questionnaire - minimum value = 17- maximum value = 68 | Ten week |
| SAIQ | Self-Appraisal of Illness Questionnaire - minimum value = 17- maximum value = 68 | Eighteen week |
| SAIQ | Self-Appraisal of Illness Questionnaire - minimum value = 17- maximum value = 68 | Twenty six week |
| SCS | Revised Self-Consciousness Scale - minimum value = 0 - maximum value = 66 | First week |
| SCS | Revised Self-Consciousness Scale- minimum value = 0 - maximum value = 66 | Ten week |
| SCS | Revised Self-Consciousness Scale - minimum value = 0 - maximum value = 66 | Eighteen week |
| SCS | Revised Self-Consciousness Scale - minimum value = 0 - maximum value = 66 | Twenty six week |
| SDS | Social Desirability Scale - minimum value = 0 - maximum value = 33 | First week |
| SDS | Social Desirability Scale - minimum value = 0 - maximum value = 33 | Ten week |
| SDS | Social Desirability Scale - minimum value = 0 - maximum value = 33 | Eighteen week |
| SDS | Social Desirability Scale - minimum value = 0 - maximum value = 33 | Twenty six week |
| STORI | Stage of Recovery Instrument - minimum value = 0 - maximum value = 50 | First week |
| STORI | Stage of Recovery Instrument - minimum value = 0 - maximum value = 50 | Ten week |
| STORI | Stage of Recovery Instrument - minimum value = 0 - maximum value = 50 | Eighteen week |
| STORI | Stage of Recovery Instrument - minimum value = 0 - maximum value = 50 | Twenty six week |
A test assessing first and second degree theory of mind through short stories and pictures involved two or three characters - minimum value = 0 - maximum value = 60
| Ten week week |
| FAUX-PAS Test | A test assessing first and second degree theory of mind through short stories and pictures involved two or three characters - minimum value = 0 - maximum value = 60 | Eighteen week week |
| FAUX-PAS Test | A test assessing first and second degree theory of mind through short stories and pictures involved two or three characters - minimum value = 0 - maximum value = 60 | Twenty six week |
| The Rey/Taylor complex figure test | The test is a neuropsychological assessment in which examinees are asked to reproduce a complicated line drawing, first by ping it freehand and then drawing from memory. This test permits the evaluation of visuospatial abilities, memory, attention, planning and working memory - minimum value = 0 - maximum value = 36 | First week |
| The Rey/Taylor complex figure test | The test is a neuropsychological assessment in which examinees are asked to reproduce a complicated line drawing, first by ping it freehand and then drawing from memory. This test permits the evaluation of visuospatial abilities, memory, attention, planning and working memory - minimum value = 0 - maximum value = 36 | Ten week |
| The Rey/Taylor complex figure test | The test is a neuropsychological assessment in which examinees are asked to reproduce a complicated line drawing, first by ping it freehand and then drawing from memory. This test permits the evaluation of visuospatial abilities, memory, attention, planning and working memory - minimum value = 0 - maximum value = 36 | Eighteen week |
| The Rey/Taylor complex figure test | The test is a neuropsychological assessment in which examinees are asked to reproduce a complicated line drawing, first by ping it freehand and then drawing from memory. This test permits the evaluation of visuospatial abilities, memory, attention, planning and working memory - minimum value = 0 - maximum value = 36 | Twenty six week |
| MEM IV Logical Memory | Composite score of the Weschler Memory Scale - fourth edition | First week |
| MEM IV Logical Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | Ten week |
| MEM IV Logical Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | Eighteen week |
| MEM IV Logical Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | Twenty six week |
| MEM IV Symbol Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | First week |
| MEM IV Symbol Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | Ten week |
| MEM IV Symbol Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | Eighteen week |
| MEM IV Symbol Memory | Composite score of the Weschler Memory Scale - fourth edition - minimum value = 0 - maximum value = 20 | Twenty six week |
| The Balloon Analogue Risk Task | The Balloon Analogue Risk Task is a computerized measure of risk taking behavior - no minimum or maximum value | First week |
| The Balloon Analogue Risk Task | The Balloon Analogue Risk Task is a computerized measure of risk taking behavior - no minimum or maximum value | Ten week |
| The Balloon Analogue Risk Task | The Balloon Analogue Risk Task is a computerized measure of risk taking behavior - no minimum or maximum value | Eighteen week |
| The Balloon Analogue Risk Task | The Balloon Analogue Risk Task is a computerized measure of risk taking behavior - no minimum or maximum value | Twenty six week |
| D2 Test | The test is neuropsychological measure of selective and sustained attention and visual scanning speed - no minimum or maximum value | First week |
| D2 Test | The test is neuropsychological measure of selective and sustained attention and visual scanning speed - no minimum or maximum value | Ten week |
| D2 Test | The test is neuropsychological measure of selective and sustained attention and visual scanning speed - no minimum or maximum value | Eighteen week |
| D2 Test | The test is neuropsychological measure of selective and sustained attention and visual scanning speed - no minimum or maximum value | Twenty six week |
| ToM-15 | The test is a task assessing theory of mind abilities you cannot move more than one disk at a time; a disk can only be placed on another disk larger than it or on an empty location - no minimum or maximum value | First week |
| ToM-15 | The test is a task assessing theory of mind abilities you cannot move more than one disk at a time; a disk can only be placed on another disk larger than it or on an empty location - no minimum or maximum value | Ten week |
| ToM-15 | The test is a task assessing theory of mind abilities you cannot move more than one disk at a time; a disk can only be placed on another disk larger than it or on an empty location - no minimum or maximum value | Eighteen week |
| ToM-15 | The test is a task assessing theory of mind abilities you cannot move more than one disk at a time; a disk can only be placed on another disk larger than it or on an empty location - no minimum or maximum value | Twenty six week |
| Cubes Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | First week |
| Cubes Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Ten week |
| Cubes Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Eighteen week |
| Cubes Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Twenty six week |
| Visual Puzzle Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | First week |
| Visual Puzzle Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Ten week |
| Visual Puzzle Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Eighteen week |
| Visual Puzzle Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Twenty six week |
| Similiraties Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | First week |
| Similiraties Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Ten week |
| Similiraties Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Eighteen week |
| Similiraties Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Twenty six week |
| Working Memory Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | First week |
| Working Memory Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Ten week |
| Working Memory Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Eighteen week |
| Working Memory Subtest | Composite score of Weschler Adult Intelligence Scale - fourth edition - minimum value = 0 - maximum value = 20 | Twenty six week |
| URC Ville Evrard | Recruiting | Neuilly-sur-Marne | 93330 | France |
|
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| C410006 | Thor protein, Drosophila |
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