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| Name | Class |
|---|---|
| Health Research Board, Ireland | OTHER |
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The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or other psychoses.
Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with schizophrenia. Pre and Post neuropsychological assessment and Magnetic Resonance Imagery (MRI) will be used to determine the effects of CR training on
The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Remediation Therapy | Experimental | Participants will undertake approximately 30 minutes of computerized CRT training for 8 weeks, 5 days per week. They will meet a therapist once per week to discuss any difficulties, help motivation. |
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| Placebo Comparator | Placebo Comparator | Participants will meet therapist once per week but will not undertake the Computerized Cognitive remediation training. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Remediation Therapy | Other | Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline neuropsychological performance | A battery of neuropsychological tests will be used at baseline and the same tests used directly after the intervention to measure changes in attention and memory. Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory. | Directly following study treatment period |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline neuropsychological performance at 3 to 6 months post intervention | A battery of neuropsychological tests will be used at baseline and the same tests used at 3 months post intervention to measure changes in attention and memory. Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in social and occupational functioning | Social and occupational function will be measured at baseline and the same tests used directly following intervention. Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B) | Directly following study treatment period |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| April H Hargreaves, PhD | Contact | 353-1-8962465 | hargrea@tcd.ie | |
| Rachael Dillon, Bsc | Contact | 353-1-8962315 | radillon@tcd.ie |
| Name | Affiliation | Role |
|---|---|---|
| Gary J Donoghoe, DClin Psych PhD | Trinity College Dublin, Ireland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, Trinity Centre for Health Sciences, St James Hospital, James St. | Recruiting | Dublin | Dublin | 8 | Ireland |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D011618 | Psychotic Disorders |
| D003072 | Cognition Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D019965 | Neurocognitive Disorders |
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| Placebo comparator | Other | Participant meets the therapist once per week but does not carry out the CRT intervention. (Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish). |
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| 3 to 6 months post study treatment period |
| Changes from baseline in brain activation during working memory testing | Changes from baseline in brain activation during working memory testing will be measured using fMRI | Directly post study treatment period |
| Change from baseline in grey matter volume | Changes in grey matter volume from baseline will be measured at 3 months post intervention using voxel based morphometry. | Directly following study treatment period |
| Change from baseline in social and occupational functioning 3 to 6 months post intervention | Social and occupational function will be measured at baseline and the same tests used directly following intervention. Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B) | 3 to 6 months post study treatment period |