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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A02236-33 | Other Identifier | ID RCB |
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This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.
Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Semantic dementia | Diagnosis of semantic dementia (revised criteria Moreaud et al., 2008; based on Neary et al., 1998) |
| |
| Alzheimer's disease | NIAAA 2011 criteria |
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| Control | MMSE above 27, no neurological or psychiatric disorder |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metacognition tests | Other | Test on episodic or semantic memory |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metacognitive bias on the episodic predictive judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 |
| Metacognitive accuracy on the episodic predictive judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 |
| Metacognitive bias on the semantic predictive judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 |
| Metacognitive accuracy on the semantic predictive judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 |
| Metacognitive bias on episodic global judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 |
| Metacognitive bias on semantic global judgment task |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with Alzheimer's disease will be patients at the CHU of Grenoble.
Patients with Alzheimer's disease will be recruited in the CHU Grenoble, CHU Angers, CHU Bordeaux, CHU Colmar, CHU Lyon, CHU Rennes and CHUV Lausanne.
Controls will be recruited via the database "Seniors pour la Science ", https://seniorspourlascience.fr/
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| Name | Affiliation | Role |
|---|---|---|
| Olivier MOREAUD | University Hospital, Grenoble | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Angers | Angers | 49 933 | France | |||
| CHU Bordeaux |
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| ID | Term |
|---|---|
| D057180 | Frontotemporal Dementia |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D057174 | Frontotemporal Lobar Degeneration |
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). |
| End of study : around May 2022 |
| Metacognitive bias on the episodic retrospective judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 |
| Metacognitive accuracy on the episodic retrospective judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 |
| Metacognitive bias on the semantic retrospective judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 |
| Metacognitive accuracy on the semantic retrospective judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 |
| Bordeaux |
| 33000 |
| France |
| Hôpital Neurologique de Lyon | Bron | 69677 | France |
| Hôpitaux Civils Colmar | Colmar | 68024 | France |
| Chu Grenoble Alpes | Grenoble | 38043 | France |
| CHU Rennes | Rennes | 35033 | France |
| CHU Vaudois | Lausanne | 1011 | Switzerland |
| D009422 | Nervous System Diseases |
| D057177 | TDP-43 Proteinopathies |
| D019636 | Neurodegenerative Diseases |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D024801 | Tauopathies |