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To compared pregnancy outcome (Serum vitamin D level in mother and infant , preeclampsia rate, preterm birth rate, Infant birth weight, Infant length , APGAR score) between pregnant women who were given vitamin D supplementation and pregnant women who were given placebo
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin D supplemented group | Experimental | Vitamin D2 20000 IU 1 tab oral weekly start at GA 18 -22 weeks until delivery |
|
| Placebo group | Experimental | Placebo drug (Appearance same as Vitamin D2) 1 tab oral weekly start at GA 18 -22 weeks until delivery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin D 2 | Drug | Vitamin D2 20000IU 1 tab oral weekly |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Serum 25-OH vitamin D level in pregnant women | measure in nmol/L | At delivery time |
| Serum 25-OH vitamin D level in umbilicalcord blood | measure in nmol/L | At delivery time |
| Measure | Description | Time Frame |
|---|---|---|
| Preeclampsia | Measure by clinical and laboratory of preeclampsia ้high blood pressure ( >= 140/90 mmHg) with proteinuria (UPCI > 0.3 mg/dL or Urine protein 24 hours > 300 mg) or in absence of proteinuria with new onset of any of the following
|
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rajavithi hospital | Bangkok | 10400 | Thailand |
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| ID | Term |
|---|---|
| D004872 | Ergocalciferols |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| Placebo drug |
| Drug |
Placebo drugs 1 tab oral weekly |
|
| During pregnancy until delivery |
| Preterm birth | Delivery before GA 37 weeks | At delivery time |
| Infant APGAR score | Measure at delivery time score 10/10 Appearance : Cyanotic, pale all over = 0 , Peripheral cyanotic only = 1 , Pink = 2 Pulse : 0 bpm = 0 , <100 = 1, 100-140 = 2 Grimace : no response to stimulation = 0 , Grimace(facial movement ,weak cry) = 1 Cry when stimulated = 2 Activity (tone) : floppy = 0 , Some flexion = 1 , Well flexed and resisting extension = 2 Respiration : Apnoeic = 0 , Slow irregular = 1 , Strong cry = 2 | At delivery time |
| Infant birth weight | measure in kilograms | At delivery time |
| Infant length | measure in centimeters | At delivery time |
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |